Paul Vetschera
Technische Universität München
7 Papers
2 Citations
Paul Vetschera is an academic researcher from Technische Universität München. The author has contributed to research in topics: Cancer & Chemistry. The author has an hindex of 5, co-authored 7 publications.
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Papers
Calcium Sensor for Photoacoustic Imaging.
Sheryl Roberts,Markus Seeger,Yuanyuan Jiang,Anurag Mishra,Felix Sigmund,Anja Stelzl,Antonella Lauri,Panagiotis Symvoulidis,Hannes Rolbieski,Matthias Preller,X. Luís Deán-Ben,Daniel Razansky,Tanja Orschmann,Sabrina C. Desbordes,Paul Vetschera,Thorsten Bach,Vasilis Ntziachristos,Gil G. Westmeyer +17 more
TL;DR: A selective and cell-permeable calcium sensor for photoacoustics (CaSPA) is introduced, a versatile imaging technique that allows for fast volumetric mapping of photoabsorbing molecules with deep tissue penetration and to optimize for Ca2+-dependent photoacoustic signal changes.
Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy
Jiao Li,Jiao Li,Andrei Chekkoury,Jaya Prakash,Jaya Prakash,Sarah Glasl,Paul Vetschera,Benno Koberstein-Schwarz,Ivan Olefir,Vipul Gujrati,Murad Omar,Vasilis Ntziachristos +11 more
TL;DR: An optoacoustic (photoacoustic) mesoscope adapted to solid tumour imaging is developed and offered the first insights into cancer optical contrast heterogeneity in vivo at an unprecedented resolution of <50 μm throughout the entire tumour mass.
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Challenging a Preconception: Optoacoustic Spectrum Differs from the Optical Absorption Spectrum of Proteins and Dyes for Molecular Imaging.
Juan Pablo Fuenzalida Werner,Yuanhui Huang,Kanuj Mishra,Robert Janowski,Paul Vetschera,Christina Heichler,Andriy Chmyrov,Clemens Neufert,Dierk Niessing,Vasilis Ntziachristos,Andre C. Stiel +10 more
TL;DR: A multi-modal laser spectrometer (MLS) was developed to enable the simultaneous measurement of optoacoustic, absorbance, and fluorescence spectra and to show the importance of correct photophysical information as a prerequisite for spectral-unmixing for in vivo imaging.
Structure-Based Mutagenesis of Phycobiliprotein smURFP for Optoacoustic Imaging.
Juan Pablo Fuenzalida Werner,Kanuj Mishra,Yuanhui Huang,Paul Vetschera,Sarah Glasl,Andriy Chmyrov,Klaus Richter,Vasilis Ntziachristos,Andre C. Stiel +8 more
TL;DR: The results demonstrate the feasibility of structure-based mutagenesis to re-purpose fluorescent probes for OA imaging, and they may provide structure-function insights for de novo engineering of transgenic OA probes.
Beyond early development: observing zebrafish over 6 weeks with hybrid optical and optoacoustic imaging
Paul Vetschera,Benno Koberstein-Schwarz,Benno Koberstein-Schwarz,Tobias Schmitt-Manderbach,Christian Dietrich,Wibke Hellmich,Andrei Chekkoury,Panagiotis Symvoulidis,Josefine Reber,Gil G. Westmeyer,Hernán López-Schier,Murad Omar,Vasilis Ntziachristos +12 more
TL;DR: The hybrid method presented can extend optical imaging to adult zebrafish employed as model systems for studying long-term processes in development, cancer, diabetes and other disorders, including contrast from endogenous blood, water and lipids.