The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Polymer conjugates of therapeutic peptides

The present invention relates to the microbial delivery of obesity related peptides. More specifically, the invention relates to the use of genetically modified yeasts and/or lactic acid bacteria for the delivery of neuropeptides and/or peptide hormones that play a role in stimulation or inhibition of food intake and/or energy homeostasis.

Microbial intestinal delivery of obesity related peptides

Natural Extract from Whole Fruit of Banana (Musa Spp)., whether unripe or ripe, containing mainly natural Melatonin, Serotonin, Catecholamines and its precursors; amino acids tryptophan and tyrosine; mineral potassium, magnesium, phosphorous and antioxidants. Contains very minimal or no carbohydrates. Final extract is in liquid, semi solid or powder form. Extract is for mammals and animal use at doses 1 to 1,000mg in powder or equivalent to powder per day. Extract is used as nutritional supplement, medicine or adjuvant in liquid, gel, capsule, caplet or tablet form. Physical treatment, Enzymatic processes and resin extraction are mainly used for extraction. Food or pharmaceutical grade additives like preservatives or antioxidants are added for shelf life. Other extracts, vitamins, minerals and amino acids may be added for further enhancement of the effectiveness and usage. Extract is used for mammals and animals, in one or more of conditions, for mood elevation, reducing stress, anxiety and depression; increasing Basal Metabolism Rate (BMR), thermogenesis, obesity, hyperlipidemia, hypercholesterol, hypertension, diabetes, sleeping disorders, neurological disorder, muscular disorder, erectile dysfunction and to increase potassium content in the body.

Natural extract from whole banana fruit (musa spp.)

The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a Zn-α2-glycoprotein or a functional fragment thereof, methods of decreasing plasma insulin levels, methods of increasing skeletal muscle mass, and methods of bringing about a weight reduction or reduction in obesity. Also provided are pharmaceutical compositions for use thereof.

Glycoproteins having lipid mobilizing properties and therapeutic uses thereof

A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine, aspartic acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic acid, leucine, alanine, histidine, glycine, threonine, histidine, valine, and threonine, a second structural amino acid sequence having alanine, phenylalanine, serine, glutamic acid, aspartic acid, glycine, glycine, threonine, aspartic acid, alanine, aspartic acid, isoleucine, leucine, glutamic acid, alanine, glycine, glutamic acid, tryptophan, valine, and leucine, a third structural amino acid sequence having aspartic acid, alanine, glutamic acid, glycine, asparagine, proline, histidine, proline, glutamic acid, methionine, alanine, proline, aspartic acid, and valine, and a fourth structural amino acid sequence having valine, proline, glycine, glutamine, alanine, tyrosine, glutamic acid, aspartic acid, glycine, tryptophan, and aspartic acid, thereby reducing the viscosity of whole blood.

Blood viscosity-reducing agent

This invention relates to the prevention and treatment of obesity in mammals, especially humans. In particular, the invention relates to a method of treating obesity in a mammal, comprising the step of administering to the mammal a therapeutically-effective amount of an agent which increases the expression of beta-3 adrenergic receptors in the mammal, together with an agonist of the beta 3 adrenergic receptor.

Product and method for control of obesity

La presente invention concerne la prevention et le traitement de l'obesite chez les mammiferes, en particulier chez l'homme. Cette invention concerne en particulier de nouveaux produits alimentaires et de nouvelles boissons, qui sont utiles pour lutter contre l'obesite par la regulation du metabolisme des lipides et des glucides. Cette invention peut s'appliquer a la medecine humaine et a la medecine veterinaire ainsi qu'a l'elevage des animaux. Dans un premier aspect cette invention concerne un organisme utile pour produire un aliment et une boisson, qui comprend une molecule d'acide nucleique, laquelle comprend un premier segment d'acide nucleique codant pour un fragment d'hormone de croissance qui a la capacite de moduler le metabolisme des lipides, eventuellement lie de facon operationnelle a un second segment d'acide nucleique codant pour un marqueur epitope ou pour un partenaire de proteine de fusion heterologue, a condition que le premier segment d'acide nucleique ne code pas une hormone de croissance mammalienne de pleine longueur intacte. Dans un autre aspect cette invention concerne un aliment, une boisson et un additif alimentaire comprenant un fragment d'hormone de croissance qui a la capacite de moduler le metabolisme des lipides. Dans un mode de realisation cette invention concerne une cellule hote, transformee avec une molecule d'acide nucleique de l'invention. Cette cellule hote peut etre un micro-organisme utilise dans la production d'un produit alimentaire ou d'une boisson fermentes. Elle peut etre aussi une cellule de plante comestible, telle qu'un fruit ou un legume, notamment une tomate, une banane et une pomme de terre, cette liste n'etant pas exhaustive. Dans un autre mode de realisation de l'invention, cette cellule hote peut etre une cellule de mammifere transgenique, a l'exception d'une cellule humaine, tel qu'une cellule de vache, de mouton ou de chevre, mammiferes qui secretent ce fragment d'hormone de croissance dans son lait.

Produit et technique permettant de lutter contre l'obesite

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Product and method for control of obesity

Produit et technique permettant de lutter contre l'obesite