Paul Rooze
University of Nantes
8 Papers
3 Citations
Paul Rooze is an academic researcher from University of Nantes. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 3, co-authored 4 publications.
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Papers
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis
Antoine Roquilly,Antoine Roquilly,Cédric Jacqueline,Marion Davieau,Alice Molle,Abderrahmane Sadek,Cynthia Fourgeux,Paul Rooze,Alexis Broquet,Barbara Misme-Aucouturier,Tanguy Chaumette,Mickael Vourc'h,Raphaël Cinotti,Nadege Marec,Vanessa Gauttier,Hamish E G McWilliam,Frédéric Altare,Jeremie Poschmann,Jose A Villadangos,Karim Asehnoune +19 more
TL;DR: It is demonstrated that sepsis results in durable impairment of alveolar phagocytic function that is dependent on the localized expression of the inhibitory receptor SIRPα, which suggests a potential strategy to prevent hospital-acquired pneumonia.
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•Journal Article
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis (vol 21, pg 636, 2020)
Antoine Roquilly,Cédric Jacqueline,Marion Davieau,Alice Molle,Abderrahmane Sadek,Cynthia Fourgeux,Paul Rooze,Alexis Broquet,Barbara Misme-Aucouturier,Tanguy Chaumette,Mickael Vourc'h,Raphaël Cinotti,Nadege Marec,Vanessa Gauttier,Hamish E G McWilliam,Frédéric Altare,Jeremie Poschmann,Jose A Villadangos,Karim Asehnoune +18 more
TL;DR: In this article, the authors investigated the phagocytic activity of macrophages after resolution of secondary immunosuppressive signals established locally upon resolution of primary infection, and showed that SIRPα played a critical role in the establishment of the microenvironment that induced tolerogenic training.
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Mechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis
Karim Asehnoune,Paul Rooze,Chiara Robba,Marwan Bouras,Luciana Mascia,Raphaël Cinotti,Paolo Pelosi,Antoine Roquilly +7 more
TL;DR: In this article , the authors investigated the effects of low tidal volume, moderate to high PEEP, or protective ventilation on relevant clinical outcomes, including acute brain injury (trauma or haemorrhagic stroke) and in-hospital mortality.
Impact of a Quality Improvement Program on the Neurological Outcome of Patients with Traumatic Spinal Cord Injury: A Before-After Mono-Centric Study.
Raphaël Cinotti,Dominique Demeure-Dit-Latte,Pierre Joachim Mahe,Paul Langlais,Nicolas Grillot,Marwan Bouras,Alexandre Bourdiol,Paul Rooze,Kevin Buffenoir,Brigitte Perrouin-Verbe,Marie-Anne Vibet,Karim Asehnoune,Antoine Roquilly +12 more
TL;DR: After adjustment on potential confounders, an early in-ICU rehabilitation program in SCI patients was associated with higher neurological score upon ICU discharge and an early intervention phase was significantlyassociated with higher Delta ASIA.
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Influence of mechanical ventilation and loading modifications on left ventricular global longitudinal strain in patients undergoing general anesthesia: a pilot study.
Raphaël Cinotti,Thierry Le Tourneau,Nicolas Grillot,Paul Rooze,Pierre Millour,Karim Asehnoune +5 more
TL;DR: Systolic function assessed with GLS is impaired after general anesthesia and invasive mechanical ventilation in patients without cardiovascular co-morbidities but remains within normal range.
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