Paul N. Epstein
University of Louisville
88 Papers
459 Citations
Paul N. Epstein is an academic researcher from University of Louisville. The author has contributed to research in topics: Diabetic nephropathy & Oxidative stress. The author has an hindex of 38, co-authored 88 publications.
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Papers
Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy
TL;DR: Overexpression of MnSOD to the heart provided extensive protection to diabetic mitochondria and provided overall protection to the diabetic heart.
392
Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes
Xianmin Xu,Satoru Kobayashi,Kai Chen,Derek Timm,Paul A. Volden,Yuan Huang,James Gulick,Zhenyu Yue,Jeffrey Robbins,Paul N. Epstein,Qiangrong Liang +10 more
TL;DR: The findings demonstrate that the diminished autophagy is an adaptive response that limits cardiac dysfunction in type 1 diabetes, presumably through up-regulation of alternative autophagic and mitophagy.
242
Transgenic Overexpression of Aldehyde Dehydrogenase-2 Rescues Chronic Alcohol Intake–Induced Myocardial Hypertrophy and Contractile Dysfunction
TL;DR: The results suggest that transgenic overexpression of ALDH2 effectively antagonizes chronic alcohol intake–elicited myocardial hypertrophy and contractile defect through a mechanism that is associated, at least in part, with phosphorylation of ASK-1, GSK-3β, GATA4, and CREB.
202
Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice
Shirong Zheng,William T. Noonan,Naira Metreveli,Susan Coventry,Patricia M. Kralik,Edward C. Carlson,Paul N. Epstein +6 more
TL;DR: Most of the characteristics of human DN can be produced by chronic hyperglycemia in a murine model, and this model will be useful for improved understanding and treatment of DN.
169
Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species
TL;DR: Transgenic overexpression of the antioxidant metallothionein in pancreatic beta cells provided broad resistance to oxidative stress by scavenging most kinds of ROS including H2O2, peroxynitrite radical released from streptozotocin, 3-morpholinosydnonimine (SIN-1), and superoxide radical produced by xanthine/xanthine oxidase.
163