Paul M. O'Byrne
McMaster University
628 Papers
10.4K Citations
Paul M. O'Byrne is an academic researcher from McMaster University. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 104, co-authored 605 publications. Previous affiliations of Paul M. O'Byrne include Trinity College, Dublin & McMaster-Carr.
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Papers
A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.
Alba Llop-Guevara,Derek K. Chu,Tina D. Walker,Susanna Goncharova,Ramzi Fattouh,Jonathan S. Silver,Cheryl Lynn Moore,Juliana L. Xie,Paul M. O'Byrne,Anthony J. Coyle,Roland Kolbeck,Alison A. Humbles,Martin R. Stämpfli,Manel Jordana +13 more
TL;DR: Exposure to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM- CSF/IL-33/OX40L pathway.
Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic response
Amrit Singh,Masatsugu Yamamoto,Jian Ruan,Jung Young Choi,Gail M. Gauvreau,Sven Olek,Ulrich Hoffmueller,Christopher Carlsten,J. Mark FitzGerald,Louis-Philippe Boulet,Paul M. O'Byrne,Scott J. Tebbutt +11 more
TL;DR: Th17/Treg imbalance post-challenge may contribute to the development of the late phase inflammatory phenotype in allergic asthma.
Efficacy and Safety of As-Needed Budesonide-Formoterol in Adolescents with Mild Asthma.
Helen K. Reddel,Paul M. O'Byrne,J. Mark FitzGerald,Peter J. Barnes,Jinping Zheng,Stefan Ivanov,Rosa Lamarca,Margareta Puu,Vijay Alagappan,Eric D. Bateman +9 more
TL;DR: In adolescents with mild asthma, as- needed BUD-FORM was superior to as-needed terbutaline for severe exacerbation reduction, with similar efficacy to BUD maintenance.
The links between allergen skin test sensitivity, airway responsiveness and airway response to allergen
Donald W. Cockcroft,Beth E. Davis,L.-P. Boulet,Francine Deschesnes,Gail M. Gauvreau,Paul M. O'Byrne,R. M. Watson +6 more
TL;DR: Allergen‐induced early asthmatic response depends on the level of IgE sensitivity and the degree of nonallergic airway hyperresponsiveness (AHR) and can be predicted from histamine PC20 and allergen skin test endpoint.
T-regulatory cell phenotypes in peripheral blood and bronchoalveolar lavage from non-asthmatic and asthmatic subjects.
Adrian J Baatjes,Steven G. Smith,Richard M. Watson,Karen Howie,Desmond M. Murphy,Mark Larché,Judah A. Denburg,Mark D. Inman,Paul M. O'Byrne +8 more
TL;DR: An unresolved issue in T regulatory cells' cell biology is the lack of consensus on phenotypic markers that accurately define the natural Treg (nTreg) population.