Paul M. Mathews
New York University
97 Papers
813 Citations
Paul M. Mathews is an academic researcher from New York University. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 48, co-authored 97 publications. Previous affiliations of Paul M. Mathews include Nathan Kline Institute for Psychiatric Research & Université de Sherbrooke.
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Papers
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Christopher Janus,Jacqueline Pearson,JoAnne McLaurin,Paul M. Mathews,Ying Jiang,Stephen D. Schmidt,M. Azhar Chishti,Patrick Horne,Donna Heslin,Janet French,Howard T.J. Mount,Ralph A. Nixon,Marc Mercken,Catherine Bergeron,Catherine Bergeron,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop,David Westaway +18 more
TL;DR: Aβ immunization reduces both deposition of cerebral fibrillar Aβ and cognitive dysfunction in the TgCRND8 murine model of Alzheimer's disease without, however, altering total levels of Aβ in the brain, which implies that either a ∼50% reduction in dense-cored Aβ plaques is sufficient to affect cognition, or that vaccination may modulate the activity/abundance of a small subpopulation of especially toxic Aβ species.
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Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Rebecca Radde,Tristan Bolmont,Stephan A. Kaeser,Janaky Coomaraswamy,Dennis Lindau,Lars Stoltze,Michael E. Calhoun,Fabienne Jäggi,Hartwig Wolburg,Simon Gengler,Christian Haass,Bernardino Ghetti,Christian Czech,Christian Hölscher,Paul M. Mathews,Mathias Jucker +15 more
TL;DR: A novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated presenilin 1 under the control of a neuron‐specific Thy1 promoter element (APPPS1 mice) is generated, well suited for studying therapeutic strategies and the pathomechanism of amyloidsosis by cross‐breeding to other genetically engineered mouse models.
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Melanie Meyer-Luehmann,Janaky Coomaraswamy,Tristan Bolmont,Tristan Bolmont,Stephan A. Kaeser,Claudia Schaefer,Ellen Kilger,Anton Neuenschwander,Dorothee Abramowski,Peter Frey,Anneliese L. Jaton,Jean-Marie Vigouret,Paolo Paganetti,Dominic M. Walsh,Paul M. Mathews,Jorge Ghiso,Matthias Staufenbiel,Lary C. Walker,Mathias Jucker,Mathias Jucker +19 more
TL;DR: The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Aβ strains with varying biological activities reminiscent of prion strains.
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Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
W. Haung Yu,Ana Maria Cuervo,Asok Kumar,Corrinne M. Peterhoff,Stephen D. Schmidt,Ju-Hyun Lee,Ju-Hyun Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Marc Mercken,Mark R. Farmery,Lars O. Tjernberg,Ying Jiang,Ying Jiang,Karen Duff,Karen Duff,Yasuo Uchiyama,Jan Näslund,Paul M. Mathews,Paul M. Mathews,Anne M. Cataldo,Ralph A. Nixon,Ralph A. Nixon +22 more
TL;DR: It is shown that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β- amyloidosis.
Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy
Michelle Pfeifer,Sonia Boncristiano,Luca Bondolfi,A. Stalder,Thomas Deller,Matthias Staufenbiel,Paul M. Mathews,Mathias Jucker +7 more
TL;DR: Both active and passive immunization against β-amyloid peptide in mouse models reduce levels of Aβ, prevent and clear amyloid plaques, and improve cognitive behavior.
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