Paul Lloyd
University of California, San Francisco
21 Papers
117 Citations
Paul Lloyd is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Paul Lloyd include Ontario Institute for Cancer Research & University of British Columbia.
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Papers
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
Mark Gerstein,Zhi John Lu,Eric L. Van Nostrand,Chao Cheng,Bradley I. Arshinoff,Tao Liu,Kevin Y. Yip,R. Robilotto,Andreas Rechtsteiner,Kohta Ikegami,P. Alves,A. Chateigner,Marc D. Perry,Mitzi Morris,Raymond K. Auerbach,X. Feng,Jing Leng,A. Vielle,Wei Niu,Kahn Rhrissorrakrai,Ashish Agarwal,Roger P. Alexander,Galt P. Barber,Cathleen M. Brdlik,J. Brennan,Jeremy Brouillet,Adrian Carr,Ming Sin Cheung,Hiram Clawson,Sergio Contrino,Luke Dannenberg,Abby F. Dernburg,Arshad Desai,L. Dick,Andréa C. Dosé,Jiang Du,Thea A. Egelhofer,Sevinc Ercan,Ghia Euskirchen,Brent Ewing,Elise A. Feingold,Reto Gassmann,Peter J. Good,Philip Green,Francois Gullier,M. Gutwein,Mark S. Guyer,Lukas Habegger,Ting Han,Jorja G. Henikoff,Stefan R. Henz,Angie S. Hinrichs,H. Holster,Tony Hyman,A. Leo Iniguez,J. Janette,M. Jensen,Masaomi Kato,W. James Kent,E. Kephart,Vishal Khivansara,Ekta Khurana,John Kim,P. Kolasinska-Zwierz,Eric C. Lai,Isabel J. Latorre,Amber Leahey,Suzanna E. Lewis,Paul Lloyd,Lucas Lochovsky,Rebecca F. Lowdon,Yaniv Lubling,Rachel Lyne,Michael J. MacCoss,Sebastian D. Mackowiak,Marco Mangone,Sheldon J. McKay,D. Mecenas,Gennifer E. Merrihew,David M. Miller,A. Muroyama,John I. Murray,Siew Loon Ooi,Hoang Pham,T. Phippen,Elicia Preston,Nikolaus Rajewsky,Gunnar Rätsch,Heidi Rosenbaum,Joel Rozowsky,Kim Rutherford,P. Ruzanov,Mihail Sarov,Rajkumar Sasidharan,Andrea Sboner,P. Scheid,Eran Segal,Hyunjin Shin,C. Shou,Frank J. Slack,C. Slightam,Richard J.H. Smith,William C. Spencer,Eo Stinson,S. Taing,Teruaki Takasaki,D. Vafeados,Ksenia Voronina,Guilin Wang,Nicole L. Washington,Christina M. Whittle,Beijing Wu,Koon-Kiu Yan,Georg Zeller,Z. Zha,Mei Zhong,Xingliang Zhou,Julie Ahringer,Susan Strome,Kristin C. Gunsalus,Gos Micklem,X. Shirley Liu,Valerie Reinke,Stuart K. Kim,LaDeana W. Hillier,Steven Henikoff,Fabio Piano,Michael Snyder,Lincoln Stein,Jason D. Lieb,Robert H. Waterston +130 more
TL;DR: These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study
Rahul Aggarwal,Jiaoti Huang,Joshi J. Alumkal,Li Zhang,Felix Y. Feng,George Thomas,Alana S. Weinstein,Verena Friedl,Can Zhang,Owen N. Witte,Paul Lloyd,Martin E. Gleave,Christopher P. Evans,Jack F. Youngren,Tomasz M. Beer,Matthew Rettig,Christopher K. Wong,Lawrence D. True,Adam Foye,Denise Playdle,Charles J. Ryan,Primo N. Lara,Kim N. Chi,Vlado Uzunangelov,Artem Sokolov,Yulia Newton,Himisha Beltran,Francesca Demichelis,Mark A. Rubin,Joshua M. Stuart,Eric J. Small +30 more
TL;DR: The near-mutual exclusivity with DNA repair alterations suggests t-SCNC may be a distinct subset of mCRPC, and transcriptional profiling facilitates the identification of t- SCNC and novel therapeutic targets.
Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.
David A. Quigley,Ha X. Dang,Shuang G. Zhao,Paul Lloyd,Rahul Aggarwal,Joshi J. Alumkal,Adam Foye,Vishal Kothari,Marc D. Perry,Adina M. Bailey,Denise Playdle,Travis J. Barnard,Li Zhang,Jin Zhang,Jack F. Youngren,Marcin Cieslik,Abhijit Parolia,Tomasz M. Beer,George Thomas,Kim N. Chi,Martin E. Gleave,Nathan A. Lack,Amina Zoubeidi,Robert E. Reiter,Robert E. Reiter,Matthew Rettig,Owen N. Witte,Charles J. Ryan,Lawrence Fong,Won Kim,Terence W. Friedlander,Jonathan Chou,Haolong Li,Rajdeep Das,Hui Li,Ruhollah Moussavi-Baygi,Hani Goodarzi,Luke A. Gilbert,Primo N. Lara,Christopher P. Evans,Theodore C. Goldstein,Theodore C. Goldstein,Joshua M. Stuart,Scott A. Tomlins,Daniel E. Spratt,R. Keira Cheetham,Donavan T. Cheng,Kyle Kai-How Farh,Julian S. Gehring,Jörg Hakenberg,Arnold Liao,P. G. Febbo,John Shon,Brad Sickler,Serafim Batzoglou,Karen E. Knudsen,Housheng Hansen He,Jiaoti Huang,Alexander W. Wyatt,Scott M. Dehm,Alan Ashworth,Arul M. Chinnaiyan,Christopher G. Maher,Eric J. Small,Felix Y. Feng +64 more
TL;DR: Integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches, providing a comprehensive view of how structural variations affect critical regulators in metastatic prostate cancer.
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The Reference Genome Sequence of Saccharomyces cerevisiae: Then and Now
Stacia R. Engel,Fred S. Dietrich,Dianna G. Fisk,Gail Binkley,Rama Balakrishnan,Maria C. Costanzo,Selina S. Dwight,Benjamin C. Hitz,Kalpana Karra,Robert S. Nash,Shuai Weng,Edith D. Wong,Paul Lloyd,Marek S. Skrzypek,Stuart R. Miyasato,Matt Simison,J. Michael Cherry +16 more
TL;DR: The genome of the budding yeast Saccharomyces cerevisiae, the first completely sequenced from a eukaryote, was updated recently in its first major update since 1996 and serves as the anchor for further innovations in yeast genomic science.
Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer
Alexander W. Wyatt,Matti Annala,Rahul Aggarwal,Kevin Beja,Felix Feng,Jack F. Youngren,Adam Foye,Paul Lloyd,Matti Nykter,Tomasz M. Beer,Joshi J. Alumkal,George V Thomas,Robert E. Reiter,Matthew Rettig,Christopher P. Evans,Allen C. Gao,Kim N. Chi,Eric J. Small,Martin E. Gleave +18 more
TL;DR: This study shows that, in the majority of patients, a ctDNA assay is sufficient to identify all driver DNA alterations present in matched metastatic tissue and supports development of DNA biomarkers to guide mCRPC patient management based on ct DNA alone.