Paul Lee
Hong Kong Baptist University
4 Papers
2 Citations
Paul Lee is an academic researcher from Hong Kong Baptist University. The author has contributed to research in topics: Chemistry & Virtual screening. The author has an hindex of 3, co-authored 4 publications.
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Papers
Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer.
Daniel Shiu-Hin Chan,Hui Yang,Maria Hiu-Tung Kwan,Zhen Cheng,Paul Lee,Li-Ping Bai,Zhi-Hong Jiang,Chun-Yuen Wong,Wang-Fun Fong,Chung-Hang Leung,Dik-Lung Ma +10 more
TL;DR: High-throughput virtual screening is used to identify FDA-approved drug methylene blue (MB) as a promising scaffold for binding the c-myc oncogene G-quadruplex DNA and to identify MB derivatives containing side chains that could interact with the G- quadruplex grooves.
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VITLE Experience: HKBU Library Supporting e‐Learning in a SARS Environment
TL;DR: Hong Kong Baptist University (HKBU) library participated in VITLE classes in 2003 as discussed by the authors, which was probably the only one involving the direct participation of an academic library in the curriculum development process.
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Molecular modeling of drug-DNA interactions: virtual screening to structure-based design
TL;DR: This review highlights some successful applications of molecular modeling in virtual ligand screening and structure-based design of organic and inorganic molecules that target non-canonical nucleic acid structures such as G-quadruplex and triplex DNA.
Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate
Dik-Lung Ma,Maria Hiu-Tung Kwan,Daniel Shiu-Hin Chan,Paul Lee,Hui Yang,Victor Pui-Yan Ma,Li-Ping Bai,Zhi-Hong Jiang,Chung-Hang Leung +8 more
TL;DR: The first application of crystal violet as a selective fluorescent switch-on probe for i-motif DNA has been reported and this interaction has been exploited to develop a label-free DNA-based "OR" logic gate for potassium and hydrogen ions.