Paul Kussie
ImClone Systems
35 Papers
697 Citations
Paul Kussie is an academic researcher from ImClone Systems. The author has contributed to research in topics: Growth factor receptor & Heparanase. The author has an hindex of 26, co-authored 34 publications. Previous affiliations of Paul Kussie include Columbia University & Eli Lilly and Company.
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Papers
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Shiqing Li,Karl R. Schmitz,Karl R. Schmitz,Philip D. Jeffrey,Jed J.W. Wiltzius,Paul Kussie,Kathryn M. Ferguson,Kathryn M. Ferguson +7 more
TL;DR: It is suggested that cetuximab interacts exclusively with domain III of sEGFR, partially occluding the ligand binding region on this domain and sterically preventing the receptor from adopting the extended conformation required for dimerization contribute to potent inhibition of EGFR activation.
1.1K
•Journal Article
A Fully Human Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor Blocks Ligand-Dependent Signaling and Inhibits Human Tumor Growth in Vivo
Douglas Burtrum,Zhenping Zhu,Dan Lu,Donna Marie Anderson,Marie Prewett,Daniel S. Pereira,Rajiv Bassi,Rashed Abdullah,Andrea T. Hooper,Henry Koo,Xenia Jimenez,Danielle P. Johnson,Robin Apblett,Paul Kussie,Peter Bohlen,Larry Witte,Daniel J. Hicklin,Dale L. Ludwig +17 more
TL;DR: Results demonstrate that A12 possesses strong antitumor activity in vitro and in vivo and may therefore be an effective therapeutic candidate for the treatment of cancers that are dependent on IGF-IR signaling for growth and survival.
Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity.
Zhenping Zhu,Koichi Hattori,Haifan Zhang,Xenia Jimenez,Dale L. Ludwig,Sergio Dias,Paul Kussie,Henry Koo,H J Kim,Dan Lu,Meilin Liu,Rafael Tejada,Matthias Friedrich,Peter Bohlen,Larry Witte,Shahin Rafii +15 more
TL;DR: Two fully human anti-KDR antibodies are produced, from Fab fragments originally isolated from a large antibody phage display library, that strongly inhibited VEGF-induced migration of human leukemia cells in vitro, and when administered in vivo, significantly prolonged survival of NOD-SCID mice inoculated withhuman leukemia cells.
226
Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Yang Yang,Veronica MacLeod,Manali S. Bendre,Yan Huang,Allison Theus,Hua-Quan Miao,Paul Kussie,Shmuel Yaccoby,Joshua Epstein,Larry J. Suva,Thomas J. Kelly,Ralph D. Sanderson +11 more
TL;DR: It is indicated that heparanase is a critical determinant of myeloma dissemination and growth in vivo and described a novel experimental animal model for examining the spontaneous metastasis of bone-homing tumors.
145
•Journal Article
Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability.
Francesca-Fang Liao,Jacqueline Doody,Jay Overholser,Bridget Finnerty,Rajiv Bassi,Yan Wu,Elisabetta Dejana,Paul Kussie,Peter Bohlen,Daniel J. Hicklin +9 more
TL;DR: Findings indicate that VE-cadherin can be selectively targeted during states of pathological angiogenesis, despite its ubiquitous distribution throughout the entire vasculature.
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