Paul Gibson
St. Jude Children's Research Hospital
6 Papers
1 Citations
Paul Gibson is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medulloblastoma & CXCL3. The author has an hindex of 5, co-authored 6 publications.
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Papers
Subtypes of medulloblastoma have distinct developmental origins
Paul Gibson,Yiai Tong,Giles W. Robinson,Margaret C. Thompson,D. Spencer Currle,Christopher G Eden,Tanya A. Kranenburg,Twala L. Hogg,Helen Poppleton,Julie Martin,David B. Finkelstein,Stanley Pounds,Aaron Weiss,Zoltan Patay,Matthew A. Scoggins,Robert J. Ogg,Yanxin Pei,Zeng-Jie Yang,Sonja N. Brun,Youngsoo Lee,Frederique Zindy,Janet C. Lindsey,Makoto Mark Taketo,Frederick A. Boop,Robert A. Sanford,Amar Gajjar,Steven C. Clifford,Martine F. Roussel,Peter J. McKinnon,David H. Gutmann,David W. Ellison,Robert J. Wechsler-Reya,Richard J. Gilbertson +32 more
TL;DR: Evidence is provided that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem, the first evidence, to the authors' knowledge, that subtypes of medULLoblastomas have distinct cellular origins.
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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Liqin Zhu,Paul Gibson,D. Spencer Currle,Yiai Tong,Robert J. Richardson,Ildar T. Bayazitov,Helen Poppleton,Stanislav S. Zakharenko,David W. Ellison,Richard J. Gilbertson +9 more
TL;DR: It is shown that Prom1 is expressed in a variety of developing and adult tissues and marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1+ tumour cells.
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WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum
Yanxin Pei,Sonja N. Brun,Sonja N. Brun,Shirley L. Markant,Shirley L. Markant,William Lento,Paul Gibson,Makoto Mark Taketo,Marco Giovannini,Richard J. Gilbertson,Robert J. Wechsler-Reya,Robert J. Wechsler-Reya +11 more
TL;DR: Investigation of the effects of canonical WNT signaling on two important classes of progenitors in the developing cerebellum: multipotent neural stem cells (NSCs) and granule neuron precursors (GNPs) shows that WNT pathway activation in vitro promotes proliferation of NSCs but not GNPs.
An integrated in vitro and in vivo high throughput screen identifies treatment leads for ependymoma
Jennifer M. Atkinson,Anang A. Shelat,Angel M. Carcaboso,Tanya A. Kranenburg,Leggy A. Arnold,Nidal Boulos,Karen Wright,Robert A. Johnson,Helen Poppleton,Kumarasamypet M. Mohankumar,Clementine Feau,Timothy N. Phoenix,Paul Gibson,Liqin Zhu,Yiai Tong,Christopher J. Eden,David W. Ellison,Waldemar Priebe,Dimpy Koul,W. K. Alfred Yung,Amar Gajjar,Clinton F. Stewart,R. Kiplin Guy,Richard J. Gilbertson +23 more
TL;DR: This comprehensive approach advances understanding of the biology and treatment of ependymoma including the discovery of several treatment leads for immediate clinical translation.
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Abstract 3448: Subtypes of medulloblastoma have distinct developmental origins
Paul Gibson,Yiai Tong,Giles W. Robinson,Helen Poppleton,Margaret C. Thompson,David S. Currle,Christopher J. Eden,Twala L. Hogg,David Finkelstein,Stanley Pounds,Zoltan Patay,Matthew A. Scoggins,Yanxin Pei,Robert J. Ogg,Youngsoo Lee,Frederique Zindy,Janet C. Lindsey,Frederic A. Boop,Amar Gajjar,Steven C. Clifford,Martine F. Roussel,Peter J. McKinnon,David W. Ellison,Robert J. Wechsler-Reya,David H. Gutmann,Richard J. Gilbertson +25 more
TL;DR: Evidence is provided that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1, arises outside the cerebellum from cells of the lower rhombic lip (LRL).
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