Paul E. Irving
Research Triangle Park
10 Papers
180 Citations
Paul E. Irving is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 7, co-authored 10 publications.
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Papers
The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists.
TL;DR: Data is presented to show that a single receptor can demonstrate varying agonist potency ratios in different host cells, consistent with the idea that these different agonists produce arrays of active states that differentially use G proteins.
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Expression Cloning and Receptor Pharmacology of Human Calcitonin Receptors from MCF-7 Cells and Their Relationship to Amylin Receptors
Wen Ji Chen,Susan Armour,James M. Way,Grace Chen,Chris Watson,Paul E. Irving,Jeff E. Cobb,Sue H. Kadwell,Kevin Beaumont,Thomas J. Rimele,Terry P. Kenakin +10 more
TL;DR: Human breast cell carcinoma MCF-7 cells were found to bind 125I-labeled rat amylin (rAmylin) and the peptide isylin antagonist radioligand125I-AC512 with high affinity, and the agonists hCAL and rAmylin were much more potent in displacing their radiolIGand counterparts than was the antagonist radiolaigand 125I -AC512.
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2-(Anilinomethyl)imidazolines as α1 Adrenergic Receptor Agonists: the Discovery of α1a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues
Stephen J. Hodson,Michael J. Bishop,Jason D. Speake,Frank Navas,Deanna T. Garrison,Eric C. Bigham,David L. Saussy,James A Liacos,Paul E. Irving,M. Jeffrey Gobel,Bryan W. Sherman +10 more
TL;DR: While sulfides were generally potent, nonselective agonists, sulfones exhibited α1a subtype selectivity in a cell-based functional assay, and Sulfone (32) was 250−7000-fold selective forα1a vs all other subtypes.
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α1-Adrenoceptor Agonists: The Identification of Novel α1A Subtype Selective 2′-Heteroaryl-2-(phenoxymethyl)imidazolines
Michael J. Bishop,Kevin A Barvian,Judd Berman,Eric C. Bigham,Deanna T. Garrison,Michael J Gobel,Stephen J. Hodson,Paul E. Irving,James A Liacos,Frank Navas,David L. Saussy,Jason D. Speake +11 more
TL;DR: Novel 2′-heteroaryl-2-(phenoxymethyl)imidazolines and α 1A Subtype selective agonists have been identified as potent agonists of the cloned human α 1 -adrenoceptors in vitro.
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2-(Anilinomethyl)imidazolines as α1 adrenergic receptor agonists: α1a subtype selective 2′-heteroaryl compounds
Jason D. Speake,Frank Navas,Michael J. Bishop,Deanna T. Garrison,Eric C. Bigham,Stephen J. Hodson,David L. Saussy,Jim A. Liacos,Paul E. Irving,Bryan W. Sherman +9 more
TL;DR: The structure-activity relationship of 2'-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as alpha(1) adrenergic agonists was investigated in this paper.
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