Paul D. Morton
National Institutes of Health
4 Papers
Paul D. Morton is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 4 publications.
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Papers
Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation.
TL;DR: Key time windows of development during which the immature brain is vulnerable to injury are described and special emphasis is placed on the dynamic nature of cellular events and how CHD may adversely impact the cellular units and networks necessary for proper cognitive and motor function.
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Abnormal neurogenesis and cortical growth in congenital heart disease.
Paul D. Morton,Ludmila Korotcova,Bobbi K. Lewis,Shivaprasad Bhuvanendran,Shruti D. Ramachandra,David Zurakowski,Jiangyang Zhang,Susumu Mori,Joseph A. Frank,Richard A. Jonas,Vittorio Gallo,Nobuyuki Ishibashi +11 more
TL;DR: It is shown that the piglet SVZ resembles its human counterpart and displays robust postnatal neurogenesis, and evidence that SVZ NSPCs migrate to the frontal cortex and differentiate into interneurons in a region-specific manner is presented.
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Microstructural Alterations and Oligodendrocyte Dysmaturation in White Matter After Cardiopulmonary Bypass in a Juvenile Porcine Model.
Gary R. Stinnett,Stephen Lin,Alexandru Korotcov,Alexandru Korotcov,Ludmila Korotcova,Paul D. Morton,Shruti D. Ramachandra,Angeline Pham,Sonali Kumar,Kota Agematsu,David Zurakowski,Paul C. Wang,Paul C. Wang,Richard A. Jonas,Nobuyuki Ishibashi +14 more
TL;DR: Reducing alterations of oligodendrocyte development in the frontal cortex can be both a metric and a goal to improve neurodevelopmental impairment in the congenital heart disease population.
Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease
Jennifer Romanowicz,Camille Leonetti,Zaenab Dhari,Ludmila Korotcova,Shruti D. Ramachandra,Nemanja Saric,Paul D. Morton,Shivani Bansal,Amrita K. Cheema,Vittorio Gallo,Richard A. Jonas,Nobuyuki Ishibashi +11 more
TL;DR: Repurposing BH4 for use during fetal brain development may limit white matter dysmaturation in congenital heart disease and mitigates the toxic effects of hypoxia on white matter.