Patrizia Corsi
University of Bari
44 Papers
316 Citations
Patrizia Corsi is an academic researcher from University of Bari. The author has contributed to research in topics: mdx mouse & Duchenne muscular dystrophy. The author has an hindex of 15, co-authored 44 publications.
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Papers
Severe alterations of endothelial and glial cells in the blood‐brain barrier of dystrophic mdx mice
Beatrice Nico,Antonio Frigeri,Grazia Paola Nicchia,Patrizia Corsi,Domenico Ribatti,Fabio Quondamatteo,Rainer Herken,Francesco Girolamo,Andrea Marzullo,Maria Svelto,Luisa Roncali +10 more
TL;DR: The findings indicate that dystrophin deficiency in the mdx brain leads to severe injury of the endothelial and glial cells with disturbance in α‐actin cytoskeleton, ZO‐1, claudin‐ 1, and AQP4 assembly, as well as BBB breakdown.
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Altered blood–brain barrier development in dystrophic MDX mice
Beatrice Nico,G. Paola Nicchia,Antonio Frigeri,Patrizia Corsi,Domenica Mangieri,Domenico Ribatti,Maria Svelto,Luisa Roncali +7 more
TL;DR: The results demonstrate that a reduction in dystrophin isoforms (Dp71) at glial endfeet leads to an altered development of the BBB, whose no-closure might contribute to the neurological dysfunctions associated with DMD.
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Identification and cDNA cloning of a new member of the L2/HNK-1 family of neural surface glycoproteins.
Gianfranco Gennarini,Gianfranco Gennarini,Geneviève Rougon,F. Vitiello,Patrizia Corsi,C. Di Benedetta,Christo Goridis +6 more
TL;DR: Rabbit antibodies raised against a 135‐ to 140‐kD glycoprotein isolated from the culture medium of mouse forebrain explants were used for the identification and cloning of a complex of mouse neural cell surface glycoproteins, predicting that the F3 surface proteins also are involved in cellinteraction phenomena.
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F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.
Antonella Bizzoca,Patrizia Corsi,Angela Polizzi,Marco F. Pinto,Dia Xenaki,Andrew J.W. Furley,Gianfranco Gennarini +6 more
TL;DR: The modified F3/Contactin profile results in delayed corticogenesis, as judged by downregulation in upper and lower layer marker expression and by BrdU birth dating, indicating that, in this transgenic model, increased F3 /Contactin levels counteract neuronal precursor commitment.
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Developmental expression of ZO-1 antigen in the mouse blood-brain barrier.
Beatrice Nico,Fabio Quondamatteo,Rainer Herken,Andrea Marzullo,Patrizia Corsi,Mirella Bertossi,Giangiuseppe Russo,Domenico Ribatti,Luisa Roncali +8 more
TL;DR: The results indicate that the ZO-1 protein is a specific molecular marker in the developing brain endothelial tight junctions and that its expression takes place parallel to BBB morphofunctional maturation.
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