Patrick TomHon
10 Papers
Patrick TomHon is an academic researcher. The author has contributed to research in topics: Hyperpolarization (physics) & Chemistry. The author has an hindex of 2, co-authored 6 publications.
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Papers
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo
Keilian MacCulloch,Austin Browning,David Guarin Bedoya,S. J. McBride,Mustapha B. Abdulmojeed,Carlos Dedesma,Boyd M. Goodson,Matthew S. Rosen,Eduard Y. Chekmenev,Yi-Fen Yen,Patrick TomHon,Thomas Theis +11 more
TL;DR: A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging.
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Triplet Photosensitized para-Hydrogen Induced Polarization
Emily E. Brown,Iuliia Mandzhieva,Patrick TomHon,Thomas Theis,Felix N. Castellano +4 more
TL;DR: In this paper , a triplet photoensitizer was used to sensitize the triplet ligand-field states in the d6-transition metal dihydride Ru(CO)(PPh3)3(H)2 (1).
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Spin dynamics of [1,2-13C2]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields.
Austin Browning,Keilian MacCulloch,Patrick TomHon,Iuliia Mandzhieva,Eduard Y. Chekmenev,Boyd M. Goodson,Sören Lehmkuhl,Thomas Theis +7 more
TL;DR: In this article , the authors analyzed the [1,2-13C2] pyruvate-SABRE spin system and its field dependence theoretically and experimentally, and provided first-principles analysis of the governing 4-spin dihydride-13c2 Hamiltonian and numerical spin dynamics simulations of the 7-spin diferent system.
2
Machine Learning-Guided Optimization of SABRE Hyperpolarization for α-Ketoglutarate in Acetone-Water.
Erica Curran,S. Sadeghi,Stephen McBride,Karl Mattsson,Megan Pike,Rielly J Harrison,Mustapha B Abdulmojeed,Franziska Theiss,Patrick TomHon,Eduard Y. Chekmenev,Milad Abolhasani,Thomas Theis +11 more
TL;DR: Machine learning-guided Bayesian optimization enhances SABRE hyperpolarization of α-ketoglutarate, achieving a 7.3-fold increase in polarization from 0.90% to 6.6%, providing chemical insights for optimized sample compositions and efficient metabolic monitoring.
Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole.
Keilian MacCulloch,Austin Browning,Patrick TomHon,Sören Lehmkuhl,Eduard Y. Chekmenev,Thomas Theis +5 more
TL;DR: In this paper , signal amplification by reversible exchange (SABRE) is employed for simultaneous chemical exchange of parahydrogen and nitrile-containing anticancer drugs (letrozole or anastrozoles) to enhance 15N polarization.