Patrick T. Franke
Aarhus University
19 Papers
199 Citations
Patrick T. Franke is an academic researcher from Aarhus University. The author has contributed to research in topics: Organocatalysis & Enantioselective synthesis. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Patrick T. Franke include University of Toronto & National Research Foundation of South Africa.
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Papers
Organocatalytic asymmetric synthesis of functionalized 3,4-dihydropyran derivatives.
TL;DR: The screening of different secondary amines as catalysts in toluene revealed that (S)-2-[bis(3,5-bistrifluoromethylphenyl)trimethyl-silanyloxymethyl]pyrrolidine (4a) gave full conversion affording the 3,4-dihydropyran 3a with 72% ee (Table 1, entry 1).
Organocatalytic enantioselective one-pot synthesis and application of substituted 1,4-dihydropyridines--Hhantzsch ester analogues.
TL;DR: The one-pot reaction of alpha,beta-unsaturated aldehydes with beta-diketones or beta-ketoesters and primary amines gives optically active 2,3-substituted 1,4-dihydropyridines in moderate yields and with enantioselectivities up to 95 % ee.
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Domino C–H functionalization reactions of gem-dibromoolefins: synthesis of N-fused benzo[c]carbazoles
TL;DR: In this article, a palladium-catalyzed domino transformation of gem-dibromoolefins leading to novel polycyclic benzo[c]carbazoles is described.
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Rhodium-Catalyzed Asymmetric Cycloisomerization and Parallel Kinetic Resolution of Racemic Oxabicycles.
Charles C. J. Loh,Matthias Schmid,Robert Webster,Andy Yen,Shabnam K. Yazdi,Patrick T. Franke,Mark Lautens +6 more
TL;DR: This work reports the first rhodium-catalyzed asymmetric cycloisomerization of meso-oxabicyclic alkenes tethered to bridgehead nucleophiles, thus providing access to tricyclics scaffolds through a myriad of enantioselective C-O, C-N, and C-C bond formations.
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