Patrick N. Nation
University of Alberta
31 Papers
239 Citations
Patrick N. Nation is an academic researcher from University of Alberta. The author has contributed to research in topics: Short bowel syndrome & Parenteral nutrition. The author has an hindex of 14, co-authored 29 publications.
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Papers
Myxoma virus M-T7, a secreted homolog of the interferon-gamma receptor, is a critical virulence factor for the development of myxomatosis in European rabbits.
Karen L. Mossman,Patrick N. Nation,Joanne Macen,Michael Garbutt,Alexandra Lucas,Grant McFadden +5 more
TL;DR: It is concluded that M-T7 functions early in infection to retard inflammatory cell migration into infected tissues and disrupt the communication between sentinel immune cells at the site of primary virus infection in the subdermis and lymphocytes in the secondary lymphoid organs, thereby disabling the host from mounting an effective cellular immune response.
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Immunoprophylactic potential of cloned Shiga toxin 2 B subunit.
Paola Marcato,George L. Mulvey,Randy J. Read,Kathleen Vander Helm,Patrick N. Nation,Glen D. Armstrong +5 more
TL;DR: R rabbits that developed Stx2 B subunit-specific antibodies, as determined by immunoblot and in vitro cytotoxicity neutralization assays, survived a challenge with Stx 2 holotoxin, thought to be the first demonstration of the immunoprophylactic potential of the Stx1 B sub unit.
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A Preclinical Study of the Safety and Efficacy of Occlusin™ 500 Artificial Embolization Device in Sheep
Richard J. Owen,Patrick N. Nation,Robert Polakowski,Jennifer A. Biliske,Paul B. Tiege,Irwin J. Griffith +5 more
TL;DR: In this article, the authors evaluated the safety, effectiveness, and biodegradation of a new embolic agent, Occlusin™ 503 Artificial Embolization Device (OCL 503).
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Administration of Tyrosyl Radical–Oxidized HDL Inhibits the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice
TL;DR: Administration of tyrHDL for 8 weeks resulted in significantly less atherosclerosis development in apoE-deficient mice than injection of HDL or saline, indicating molecules increasing mobilization of cellular cholesterol to apoAI for HDL particle formation would be expected to decrease Atherosclerosis without necessarily causing sustained increases in circulating HDL cholesterol levels.
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Parenteral Soy Oil and Fish Oil Emulsions: Impact of Dose Restriction on Bile Flow and Brain Size of Parenteral Nutrition-Fed Neonatal Piglets
Jessica K Josephson,Justine M. Turner,Catherine J. Field,Pamela R. Wizzard,Patrick N. Nation,Consolato Sergi,Ronald O. Ball,Paul B. Pencharz,Paul W. Wales +8 more
TL;DR: Low-dose fat emulsions reduce the risk of developing PNALD and the risk to brain development in neonates exposed to dose restriction, particularly with fish oil, is required.
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