Patrick Metzner
Centre national de la recherche scientifique
58 Papers
300 Citations
Patrick Metzner is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Claisen rearrangement & Addition reaction. The author has an hindex of 15, co-authored 58 publications. Previous affiliations of Patrick Metzner include Joseph Fourier University.
Chat about Author
Papers
First chiral selenium ylides used for asymmetric conversion of aldehydes into epoxides.
TL;DR: Enantioenriched selenonium ylides have been generated by addition of benzyl bromide to C2 symmetric (2R,5R)-2,5-dimethylselenolane and an aliphatic cyclic hypervalent dibromoselenurane structure has been demonstrated by X-ray analysis.
35
Straightforward Stereoselective Synthesis of Spiro-epoxyoxindoles.
Verena Schulz,Marion Davoust,Margareth Lemarie,Jean-François Lohier,Jana Sopkova‐de Oliveira Santos,Patrick Metzner,Jean-François Brière +6 more
Abstract: [reaction: see text] The in situ preparation of a sulfonium ylide reagent achieved the highly diastereoselective epoxidation of isatins, so that a new and straightforward access to biologically significant spiro-epoxyoxindoles is provided. The first investigations of an asymmetric version are reported with enantiopure sulfides.
First use of axially chiral thioamides for the stereocontrol of C-C bond formation
TL;DR: Several N-aryl-substituted thioamides with an axis of chirality along the N-C(aryl) bond were prepared in good to excellent yields and chemical correlation allowed the assignment of the (aR*,2R*) configuration to the major diastereoisomer.
32
Direct synthesis of sulfines by oxidation of enethiolizable thioketones
TL;DR: In contrast to literature expectations, direct synthesis of aliphatic sulfines by oxidation of thiocarbonyl compounds is not possible; no divinyl disulfide has been formed as discussed by the authors.
32
Catalytic ferrocenyl sulfides for the asymmetric transformation of aldehydes into epoxides
TL;DR: In this paper, six ferrocenyl sulfides, exhibiting planar and central chiralities, have been screened as a catalytic source of asymmetric sulfonium ylides.
29