Patrick Martigne
8 Papers
115 Citations
Patrick Martigne is an academic researcher. The author has contributed to research in topics: Biodosimetry & Bone marrow. The author has an hindex of 6, co-authored 8 publications.
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Papers
Laboratory intercomparison of the dicentric chromosome analysis assay.
Christina Beinke,Stephen Barnard,H. Boulay-Greene,A. De Amicis,S. De Sanctis,F. Herodin,A. Jones,Ulrike Kulka,Florigio Lista,David Lloyd,Patrick Martigne,Jayne Moquet,Ursula Oestreicher,Horst Romm,Kai Rothkamm,M. Valente,Viktor Meineke,Herbert Braselmann,Michael Abend +18 more
TL;DR: No significant differences were found for dose estimates based either on 20, 30, 40 or 50 cells, suggesting that the scored number of cells can be reduced from 50 to 20 without loss of precision of triage dose estimates, at least for homogenous exposure scenarios.
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Laboratory intercomparison of the cytokinesis-block micronucleus assay.
Horst Romm,Stephen Barnard,H. Boulay-Greene,A. De Amicis,S. De Sanctis,M. Franco,F. Herodin,A. Jones,Ulrike Kulka,Florigio Lista,Patrick Martigne,Jayne Moquet,Ursula Oestreicher,Kai Rothkamm,Hubert Thierens,M. Valente,Veerle Vandersickel,Anne Vral,Herbert Braselmann,Viktor Meineke,Michael Abend,Christina Beinke +21 more
TL;DR: The focus of the study is an intercomparison of laboratories' dose-assessment performances using the cytokinesis-block micronucleus (CBMN) assay as a diagnostic triage tool for individual radiation dose assessment.
DosiKit, a New Portable Immunoassay for Fast External Irradiation Biodosimetry.
Julie Bensimon Etzol,Marco Valente,Sandrine Altmeyer,Caroline Bettencourt,Samuel Bouvet,Guillaume Cosler,François Desangles,Michel Drouet,F. Entine,Francis Herodin,Flora Jourquin,Yannick Lecompte,Patrick Martigne,X. Michel,Jérôme Pateux,Nicolas Ugolin,Sylvie Chevillard +16 more
TL;DR: It is shown that, despite significant inter-individual variations, DosiKit can estimate total-body irradiation doses from 0.5 to 10 Gy with a strong linear dose-dependent signal and can be used to classify potentially exposed individuals into three dose ranges: below 2 Gy, between 2 and 5 Gy and above 5 Gy.
9
Experimental Quantification of Delayed Radiation-Induced Organ Damage in Highly Irradiated Rats With Bone Marrow Protection: Effect of Radiation Dose and Organ Sensitivity.
François-Xavier Boittin,Patrick Martigne,Jean-François Mayol,Josiane Denis,Florent Raffin,David Coulon,Nancy Grenier,Michel Drouet,Francis Herodin +8 more
TL;DR: The complex evolution of organ damage presented in this paper offers the possibility to explore and then validate specific therapeutic windows using candidate drugs targeted to each injured visceral organ.
8
The extent of irradiation-induced long-term visceral organ damage depends on cranial/brain exposure.
François-Xavier Boittin,Josiane Denis,Jean-François Mayol,Patrick Martigne,Florent Raffin,David Coulon,Nancy Grenier,Michel Drouet,Francis Herodin +8 more
TL;DR: Results demonstrate the influence of cranial/brain exposure in the onset of organ damage and suggest that the attenuated organ damage in hind limbs-protected rats may be in part related to reduced acute and chronic inflammation.