Patrick M. Wright
United States Department of the Army
4 Papers
66 Citations
Patrick M. Wright is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Clostridium botulinum & Toxin. The author has an hindex of 3, co-authored 4 publications.
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Papers
A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.
Jean Mukherjee,Jacqueline M. Tremblay,Clinton E. Leysath,Kwasi Ofori,Karen Baldwin,Xiaochuan Feng,Daniela Bedenice,Robert P. Webb,Patrick M. Wright,Leonard A. Smith,Saul Tzipori,Charles B. Shoemaker +11 more
TL;DR: A single, easy-to-produce recombinant protein was as efficacious as polyclonal antiserum in a clinically-relevant mouse model of botulism and should have widespread application in antitoxin development and other therapies in which neutralization and/or accelerated clearance of a serum biomolecule can offer therapeutic benefit.
Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3.
TL;DR: Differences in protective immunity diminished after multiple vaccinations with either ciBoNT/A1 HP or BoNT/ a1 H(c), and the survival rates were more comparable at the toxin levels used to challenge.
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Protection with Recombinant Clostridium botulinum C1 And D Binding Domain Subunit (Hc) Vaccines Against C and D Neurotoxins
Robert P. Webb,Theresa J. Smith,Patrick M. Wright,Vicki A. Montgomery,Michael M. Meagher,Leonard A. Smith +5 more
TL;DR: Results indicate the recombinant C1 and D Hc vaccines are not only effective in a monovalent formula but offer complete protection against both parental and C/D mosaic toxin and partial protection against D/C mosaic toxin when delivered as a bivalent vaccine.
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Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5
Suzanne R. Kalb,Jakub Baudys,Robert P. Webb,Patrick M. Wright,Theresa J. Smith,Leonard A. Smith,Rafael A. Fernández,Brian H. Raphael,Susan E. Maslanka,John R. Barr +9 more
TL;DR: It is reported that BoNT/F5 cleaves substrate synaptobrevin-2 in a different location than the other Bo NT/F subtypes, between L and E, which is the first report of cleavage of synaptOBrevin -2 in this location.