Patrick M. Smith
Louisiana State University
12 Papers
125 Citations
Patrick M. Smith is an academic researcher from Louisiana State University. The author has contributed to research in topics: Equine herpesvirus 1 & CD8. The author has an hindex of 11, co-authored 12 publications. Previous affiliations of Patrick M. Smith include LSU Health Sciences Center Shreveport.
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Papers
Control of acute cutaneous herpes simplex virus infection : T cell-mediated viral clearance is dependent upon interferon-γ (IFN-γ)
TL;DR: Cutaneous HSV infection of the footpad tissue of C57BL/6 (B6) mice provides a model to determine the relative contribution of each T cell subset during the important early phase of the response to infection, and it was found that the neutralization of IFN-γ in vivo diminished the ability of mice to clear infectious HSV from the skin, and treatment with anti-IFN-β in vivo ablated the able of transferred T cells to mediate recovery.
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In vitro and in vivo characterization of equine herpesvirus type 1 (EHV-1) mutants devoid of the viral chemokine-binding glycoprotein G (gG).
Jens von Einem,Patrick M. Smith,Gerlinde R. Van de Walle,Dennis J. O'Callaghan,Nikolaus Osterrieder +4 more
TL;DR: It is concluded that deletion of gG in EHV-1 seems to lead to an exacerbation of respiratory disease in the mouse.
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Protective immunity against equine herpesvirus type-1 (EHV-1) infection in mice induced by recombinant EHV-1 gD
Yunfei Zhang,Patrick M. Smith,E. Bart Tarbet,E. Bart Tarbet,Nikolaus Osterrieder,Nikolaus Osterrieder,Stephen R. Jennings,Dennis J. O'Callaghan +7 more
TL;DR: Results confirm that gD plays an important role in eliciting the protective immune response against EHV-1 infection, and indicate that subunit vaccines containing preparations of gD may be very effective if delivered directly to the upper respiratory tract.
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Characterization of the Cytolytic T-Lymphocyte Response to a Candidate Vaccine Strain of Equine Herpesvirus 1 in CBA Mice
TL;DR: The results suggested that both lymphocyte subpopulations contribute to viral clearance, with either subpopulation alone being sufficient.
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Contribution of gene products encoded within the unique short segment of equine herpesvirus 1 to virulence in a murine model.
Arthur R. Frampton,Patrick M. Smith,Yunfei Zhang,Tomio Matsumura,Nikolaus Osterrieder,Dennis J. O'Callaghan +5 more
TL;DR: Findings show that gI, and/or gI and gE restore a virulent phenotype to the EHV-1 KyA strain, and indicate that virulence factors, in addition to gIand gE, contribute to the pathogenesis of the RacL11 strain.
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