Patrick M. Dolan
Johns Hopkins University
52 Papers
1.1K Citations
Patrick M. Dolan is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Calcitriol & Oltipraz. The author has an hindex of 26, co-authored 52 publications.
Chat about Author
Papers
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
Jed W. Fahey,Xavier Haristoy,Patrick M. Dolan,Thomas W. Kensler,Isabelle Scholtus,Katherine K. Stephenson,Paul Talalay,Alain Lozniewski +7 more
TL;DR: Sulforaphane, an isothiocyanate abundant as its glucosinolate precursor in certain varieties of broccoli and broccoli sprouts, is a potent bacteriostatic agent against 3 reference strains and 45 clinical isolates of H. pylori, irrespective of their resistance to conventional antibiotics.
841
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.
Soona Shin,Junko Wakabayashi,Melinda S. Yates,Nobunao Wakabayashi,Patrick M. Dolan,Susan Aja,Karen T. Liby,Michael B. Sporn,Masayuki Yamamoto,Thomas W. Kensler +9 more
TL;DR: It is indicated that CDDO-Im is an exceedingly potent agent for preventing obesity, and the Nrf2 pathway is identified as a novel target for management of obesogenesis.
300
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene–DNA adducts and tumor yield in mice
TL;DR: It is observed that oltipraz had no protective effect on tumor burden in the forestomach of nrf2-deficient mice when administered 1 h before B[a]P, a timeline that selectively optimizes for possible inhibitory effects on cytochrome P450s.
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment.
William O. Osburn,Baktiar O. Karim,Patrick M. Dolan,Guosheng Liu,Masayuki Yamamoto,David L. Huso,Thomas W. Kensler +6 more
TL;DR: The role of Nrf2 genotype in regulating an adaptive response that protects against early‐phase inflammation‐mediated tumorigenesis is illustrated.
198
Biochemical effects of dithiolthiones.
TL;DR: Dithiolthiones that are present in cabbage may play a role in the protective actions of diets high in vegetables against the toxic actions of xenobiotics, and the biochemical effects reported here may account for the protectiveactions of these compounds.
166