Patrick M. Boyle
Harvard University
20 Papers
53 Citations
Patrick M. Boyle is an academic researcher from Harvard University. The author has contributed to research in topics: Synthetic biology & Systems biology. The author has an hindex of 13, co-authored 20 publications. Previous affiliations of Patrick M. Boyle include Massachusetts Institute of Technology.
Chat about Author
Papers
Natural strategies for the spatial optimization of metabolism in synthetic biology.
TL;DR: This review highlights natural and synthetic examples of three-dimensional metabolism both inter- and intracellularly, offering tools and perspectives for biological design.
382
Development of a multiplexed microbioreactor system for high-throughput bioprocessing
Nicolas Szita,Nicolas Szita,Paolo Boccazzi,Zhiyu Zhang,Patrick M. Boyle,Anthony J. Sinskey,Klavs F. Jensen +6 more
TL;DR: The multiplexed system is used to compare two different reactor designs, demonstrating that the reproducibility of the system permits the quantification of microbioreactor performance.
169
Insulation of a synthetic hydrogen metabolism circuit in bacteria.
Christina M. Agapakis,Daniel C. Ducat,Daniel C. Ducat,Patrick M. Boyle,Edwin H Wintermute,Jeffrey C. Way,Pamela A. Silver,Pamela A. Silver +7 more
TL;DR: It is shown that a synthetic hydrogen-producing electron transfer circuit in Escherichia coli can be insulated from existing cellular metabolism via multiple approaches, in many cases improving the function of the pathway.
Systems-Level Engineering of Nonfermentative Metabolism in Yeast
TL;DR: The results demonstrate that constraint-based models can identify seemingly unrelated mutations, which interact at a systems level across subcellular compartments to modulate flux through nonfermentative metabolic pathways.
40
Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.
TL;DR: A cell-based RNAi screen reveals an extensive network of genes, including UCP5, which directs nuclear localization of FOXO1a, creating a link to the Akt signaling network.
37