Patrick Lombard
University College London
8 Papers
5 Citations
Patrick Lombard is an academic researcher from University College London. The author has contributed to research in topics: Brachyury & Gene silencing. The author has an hindex of 4, co-authored 8 publications.
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Papers
Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma.
Lucia Cottone,Nadia Eden,Inga Usher,Patrick Lombard,Hongtao Ye,Lorena Ligammari,Daniel Lindsay,Sebastian Brandner,Jože Pižem,Nischalan Pillay,Nischalan Pillay,Roberto Tirabosco,Fernanda Amary,Fernanda Amary,Adrienne M. Flanagan,Adrienne M. Flanagan +15 more
- 08 Jan 2020
TL;DR: It was identified that mRNA levels were comparable in tumours with and without p16 protein expression, but other events including DNA promoter hypermethylation, copy number neutral loss of heterozygosity and expression of candidate microRNAs previously implicated in the regulation of CDKN2A expression were not identified to explain the protein loss.
53
H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours
Iben Lyskjaer,Daniel Lindsay,Daniel Lindsay,Roberto Tirabosco,Christopher D. Steele,Patrick Lombard,Anna-Christina Strobl,Ana M Rocha,Christopher Davies,Hongtao Ye,Elise Bekers,Julia Ingruber,Matt Lechner,Fernanda Amary,Fernanda Amary,Nischalan Pillay,Nischalan Pillay,Adrienne M. Flanagan,Adrienne M. Flanagan +18 more
TL;DR: It is demonstrated that loss of H3K27me3 expression occurs overall in 38% of MPNSTs, but is lost in 76% of histologically classical cases, whereas loss was detected in only 23% cases with heterologous elements and 14% where the diagnosis could not be provided on morphology alone.
29
Drivers underpinning the malignant transformation of giant cell tumour of bone
Matthew Fittall,Matthew Fittall,Matthew Fittall,Iben Lyskjaer,Iben Lyskjaer,Peter Ellery,Patrick Lombard,Jannat Ijaz,Anna Christina Strobl,Dahmane Oukrif,Maxime Tarabichi,Maxime Tarabichi,Martin Sill,Christian Koelsche,Gunhild Mechtersheimer,Jonas Demeulemeester,Jonas Demeulemeester,Roberto Tirabosco,Fernanda Amary,Peter J. Campbell,Stefan M. Pfister,Stefan M. Pfister,David T.W. Jones,David T.W. Jones,Nischalan Pillay,Nischalan Pillay,Peter Van Loo,Peter Van Loo,Sam Behjati,Sam Behjati,Adrienne M. Flanagan,Adrienne M. Flanagan +31 more
TL;DR: The genomic and methylation patterns underlying the rare clinical phenomena of benign metastasising and malignant transformation of GCTB are reported and how the combination of genomic and epigenomic findings could potentially distinguish benign from malignant GCTBs is shown, thereby predicting aggressive behaviour in challenging diagnostic cases is shown.
28
Drivers underpinning the malignant transformation of giant cell tumour of bone
Matthew Fittall,Peter Ellery,Iben Lyskjaer,Patrick Lombard,Jannat Ijaz,Anna C Strobl,Dahmane Oukrif,Maxime Tarabichi,Martin Sill,Christian Koelsche,Jonas Demeulemeester,Grace Collord,Roberto Tirabosco,Fernanda Amary,Peter J. Campbell,Stefan M. Pfister,David T.W. Jones,Nischalan Pillay,Peter Van Loo,Sam Behjati,Adrienne M. Flanagan +20 more
TL;DR: The genomic and methylation patterns underlying the rare clinical phenomena of benign metastases and malignant transformation of GCTB are revealed.
16
Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival
Lucia Cottone,Edward Hookway,Adam P. Cribbs,Graham Wells,Patrick Lombard,Lorena Ligammari,Anthony Tumber,Roberto Tirabosco,Fernanda Amary,T. Szommer,Catrine Johannson,Paul Brennan,Nischalan Pillay,U. Oppermann,Adrienne M. Flanagan +14 more
TL;DR: Previous data showing that the function of TBXT is essential for maintaining notochord cell fate and function are supported and the data suggest that TBXT can potentially be targeted therapeutically by modulating epigenetic control mechanisms such as H3K27 demethylases are suggested.