Patrick Leclerc
Karolinska Institutet
15 Papers
86 Citations
Patrick Leclerc is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Arthritis & Inflammation. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Patrick Leclerc include Laval University & Karolinska University Hospital.
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Papers
Anti-inflammatory cytokine profile in early human tendon repair
TL;DR: At 2 weeks post–human Achilles tendon rupture, healing is characterized by a resolving inflammatory phase and up-regulation of IL-6, IL-8 and IL-10, suggesting that these cytokines may be associated with anti-inflammatory and regenerative effects on the tendon healing process.
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IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts.
Patrick Leclerc,Heidi Wähämaa,Helena Idborg,P.-J. Jakobsson,Helena Erlandsson Harris,Marina Korotkova +5 more
TL;DR: Investigation of the effects of IL‐1β/HMGB1 complexes on mPGES‐1 and other enzymes of the PGE2 pathway in synovial fibroblasts (SFs) from patients with arthritis found an important pathogenic mechanism perpetuating inflammatory and destructive activities in rheumatoid arthritis.
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Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice.
TL;DR: In LPS-induced peritoneal macrophages from mPGES-1 knock-out mice PGE2 production was markedly attenuated, whereas levels of PGD2 metabolites were increased compared to wild type mice and the levels of oxidized fatty acid 13-HODE were also significantly up-regulated in KO Macrophages.
35
Characterization of a new mPGES-1 inhibitor in rat models of inflammation.
Patrick Leclerc,Sven-Christian Pawelzik,Helena Idborg,Linda Spahiu,Charlotte Larsson,Patric Stenberg,Marina Korotkova,Per-Johan Jakobsson +7 more
TL;DR: Compound II represents a valuable pharmacological tool for the study of mPGES-1 inhibition in rat models and could potentially mitigate the gastro-intestinal and cardiovascular side effects seen after long-term treatment with traditional non-steroidal anti-inflammatory drugs (NSAIDs) and Coxibs respectively.
32
Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils
Patrick Leclerc,Jordane Biarc,Mireille St-Onge,Caroline Gilbert,Andrée-Anne Dussault,Cynthia Laflamme,Marc Pouliot +6 more
TL;DR: The results identify a COX-2-associated protein which may have an impact in prostanoid biosynthesis and its expression and subcellular localization in human neutrophils and its possible impact on PGE2 biosynthesis.