Patrick Lau
University of Queensland
29 Papers
539 Citations
Patrick Lau is an academic researcher from University of Queensland. The author has contributed to research in topics: Nuclear receptor & Biology. The author has an hindex of 21, co-authored 27 publications. Previous affiliations of Patrick Lau include Australian Research Council & University of Hong Kong.
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Papers
The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells
TL;DR: This work has shown that PPARβ/δ, a very low-density lipoprotein sensor, is abundantly expressed in skeletal muscle, a major mass peripheral tissue that accounts for approximately 40% of total body weight.
The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.
Patrick Lau,Rebecca L. Fitzsimmons,Suryaprakash Raichur,Shu-Ching M. Wang,Adriane Lechtken,George E.O. Muscat +5 more
TL;DR: It is suggested that this orphan nuclear receptor is a key modulator of fat accumulation and that selective ROR modulators may have utility in the treatment of obesity.
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Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.
TL;DR: Evidence for a biological role and positive influence of RORalpha1 in the cascade of events involved in the activation of myogenic-specific markers and cell cycle regulators is provided and crosstalk between theretinoid-relatedorphan (ROR) nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.
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Suppressor of cytokine signalling gene expression is elevated in breast carcinoma
Mireille Raccurt,S P Tam,Patrick Lau,Hichem C. Mertani,Anne Lambert,Tomás García-Caballero,H Li,Richard J. C. Brown,Michael A. McGuckin,Gérard Morel,Michael J. Waters +10 more
TL;DR: Increased CIS expression in breast cancer lines appears to be a specific lesion, and could simultaneously shut down STAT 5 signalling by trophic hormones, confer resistance to host cytokines and increase proliferation through ERK kinases.
Rev-erbβ Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells EVIDENCE FOR CROSS-TALK BETWEEN ORPHAN NUCLEAR RECEPTORS AND MYOKINES
TL;DR: It is speculated that selective modulators of Rev-erbbeta may have therapeutic utility in the treatment of dyslipidemia and regulation of muscle growth as well as lipid metabolism in skeletal muscle.
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