Patrick J. Morrison
Ulster University
16 Papers
85 Citations
Patrick J. Morrison is an academic researcher from Ulster University. The author has contributed to research in topics: Age of onset & Trinucleotide repeat expansion. The author has an hindex of 12, co-authored 16 publications. Previous affiliations of Patrick J. Morrison include Belfast City Hospital & Belfast Health and Social Care Trust.
Chat about Author
Papers
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
J-M Lee,Eliana Marisa Ramos,Junghee Lee,Tammy Gillis,Jayalakshmi S. Mysore,Michael R. Hayden,Simon C. Warby,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Ferdinando Squitieri,S. Orobello,S. Di Donato,Estrella Gómez-Tortosa,Carmen Ayuso,Oksana Suchowersky,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,Randi Jones,Tetsuo Ashizawa,Samuel Frank,Marie Saint-Hilaire,Steven M. Hersch,H. D. Rosas,Diane Lucente,Madeline Harrison,Andrea Zanko,Ruth K. Abramson,Karen Marder,Jorge Sequeiros,J.S. Paulsen,Georg Bernhard Landwehrmeyer,Richard H. Myers,Marcy E. MacDonald,James F. Gusella +37 more
TL;DR: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat, and the rate of HD pathogenesis leading to motor diagnosis is determined by a completely dominant action of the longest expanded allele and as yet unidentified genetic or environmental factors.
The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.
J. Michael Andresen,Javier Gayán,Luc Djoussé,Simone Roberts,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,James F. Gusella,Marcy E. MacDonald,Richard H. Myers,David E. Housman,Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Kelly Posner Gerstenhaber,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Adam M. Brickman,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,John B. Penney,Jang Ho Cha,Micheal Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Anne B. Young,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyoh,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Shelley Peery Moran,Denise Krch,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyer,Michael R. Hayden,E. Almqvist,Ryan R. Brinkman,Oksana Suchowersky,Alexandra Durr,Catherine Dodé,Ferdinando Squitieri,Patrick J. Morrison,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Adam Rosenblatt,Gómez Tortosai Estrella,David Mayo Cabrero,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,J.S. Paulsen,Randi Jones,Andrea Zanko,Tetsuo Ashizawa,Alice Lazzarini,Jian-Liang Li,Jian-Liang Li,Vanessa C. Wheeler,Ana L. Russ,Gang Xu,Jayalakshmi S. Mysore,Tammy Gillis,Michael Hakky,L. Adrienne Cupples,Marie Saint-Hilaire,Steven M. Hersch +96 more
TL;DR: In this article, a two-segment exponential regression model was proposed for age-of-obstinence analysis of the CAG repeat expansion in the HD gene, and a plot of natural log-transformed age of onset against CAG-repeat length revealed this segmental relationship.
132
Uptake of Huntington disease predictive testing in a complete population.
TL;DR: Morrison PJ, Harding‐Lester S, Bradley A. Uptake of Huntington disease predictive testing in a complete population is found to be high and consistent with previous studies.
113
Common SNP-Based Haplotype Analysis of the 4p16.3 Huntington Disease Gene Region
Jong-Min Lee,Jong-Min Lee,Tammy Gillis,Jayalakshmi S. Mysore,Eliana Marisa Ramos,Eliana Marisa Ramos,Richard H. Myers,Michael R. Hayden,Patrick J. Morrison,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Ferdinando Squitieri,Annamaria Griguoli,Stefano Di Donato,Estrella Gómez-Tortosa,Carmen Ayuso,Oksana Suchowersky,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,Randi Jones,Tetsuo Ashizawa,Samuel Frank,Marie Saint-Hilaire,Steven M. Hersch,H. D. Rosas,Diane Lucente,Madaline B. Harrison,Andrea Zanko,Ruth K. Abramson,Karen Marder,Jorge Sequeiros,Marcy E. MacDonald,Marcy E. MacDonald,James F. Gusella,James F. Gusella +38 more
TL;DR: The results argue against common local regulatory variation as a factor influencing HD pathogenesis and indicate that genome-wide association analysis with a small number of cases can be effective for regional localization of genetic defects, even when a founder effect accounts for only a fraction of the disorder.
68
Accurate prevalence and uptake of testing for Huntington's disease
TL;DR: www.thelancet.com/neurology Vol 9 December 201
40