Patrick J. Devine
Novartis
8 Papers
17 Citations
Patrick J. Devine is an academic researcher from Novartis. The author has contributed to research in topics: In vivo & Endocrine system. The author has an hindex of 3, co-authored 8 publications.
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Papers
Roles of Reactive Oxygen Species and Antioxidants in Ovarian Toxicity
TL;DR: Evidence about the potential impact of oxidative stress on the well-being of primordial, growing and preovulatory follicles, as well as oocytes and early embryos, is presented, examining cell types and molecular targets.
Animal Models for In Vivo Lactation Studies: Anatomy, Physiology and Milk Compositions in the Most Used Non-Clinical Species: A Contribution from the ConcePTION Project.
Domenico Ventrella,Nurit Ashkenazi,Alberto Elmi,Karel Allegaert,Camilla Aniballi,Anthony M. DeLise,Patrick J. Devine,Anne Smits,Lilach Steiner,Monica Forni,Michele Bouisset-Leonard,Maria Laura Bacci +11 more
TL;DR: In this paper, the main features of mammary gland anatomy, and the physiology of lactation and colostrum/milk in the most commonly used animal species for regulatory toxicity were summarized.
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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
Larraufie Marie-Helene,Xiaolin Gao,Xiaobo Xia,Patrick J. Devine,Joerg Kallen,Dong Liu,Gregory A. Michaud,Andreas Harsch,Savage Nik,Jian Ding,Kian L. Tan,Manuel Mihalic,Silvio Roggo,Stephen M. Canham,Bushell Simon,Philipp Krastel,Jinhai Gao,Aude Izaac,Erhan I. Altinoglu,Philipp Lustenberger,Michael Salcius,Fred Harbinski,Eric T Williams,Liling Zeng,Joseph Loureiro,Feng Cong,Christy Fryer,Lloyd B. Klickstein,John A. Tallarico,Rishi K. Jain,Deborah Rothman,Shaowen Wang +31 more
TL;DR: In this paper, a series of FK506 analogs were identified that act as potent BMP potentiators by sequestering FKBP12 from BMP type I receptors.
14
Immunohistochemistry and Female Reproductive Toxicology: The Ovary and Mammary Glands
Daniel G. Cyr,Patrick J. Devine,Isabelle Plante +2 more
- 01 Jan 2016
TL;DR: Given the complexity of these interactions and the need to examine how cell-specific interactions may be altered by toxicants, the need for microscopy-based analyses and immunolocalization of the proteins implicated in cell–cell interactions in reproductive tissues is highlighted.
5
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human
Francois Pognan,J. Andreas Mahl,Maria Papoutsi,David Ledieu,Marc Raccuglia,Diethilde Theil,Sarah B. Voytek,Patrick J. Devine,Katie Kubek-Luck,Natalie M. Claudio,André Cordier,Annabelle Heier,Carine Kolly,Andreas Hartmann,Salah-Dine Chibout,Page Bouchard,Christian Trendelenburg +16 more
TL;DR: The molecular mechanisms leading to siponimod-induced HSA in mice are considered species specific and likely irrelevant to humans, while it is suggested that the human cells also reproduce a lack of in vivo response to sip onimod.