Stable electrospray signal on a microfabricated glass chip with three-dimensional open edge and tiered depth geometries

Portable chemical detection platform for on-site monitoring of odorant levels in natural gas.

Ion mobility separates ion in the gas phase based on rotationally averaged cross section, a parameter often correlated with size, providing a versatile measurement strategy when integrated with mass spectrometry. The rapid growth in the field of ion mobility mass spectrometry has been catalyzed by numerous innovative advances in instrumentation that have improved resolution, sensitivity, and the ability to measure collision cross sections. These advances in ion mobility instrumentation and methods have been translated into many applications in the fields of metabolomics, lipidomics, proteomics, and structural biology. This Perspective focuses on developments in ion mobility instrumentation, spanning the impressive capabilities of commercial platforms to customized designs and modifications that establish new benchmarks at the frontiers of ion mobility mass spectrometry. 

Development and Modification of Ion Mobility Mass Spectrometry Instrumentation for Enhanced Analysis of Biological Molecules

We have developed a statistical model-based approach to the quality analysis (QA) and quality control (QC) of a gas micro pre-concentrator chip (μPC) performance when manufactured at scale for chemical and biochemical analysis of volatile organic compounds (VOCs). To test the proposed model, a medium-sized university-led production batch of 30 wafers of chips were subjected to rigorous chemical performance testing. We quantitatively report the outcomes of each manufacturing process step leading to the final functional chemical sensor chip. We implemented a principal component analysis (PCA) model to score individual chip chemical performance, and we observed that the first two principal components represent 74.28% of chemical testing variance with 111 of 118 viable chips falling into the 95% confidence interval. Chemical performance scores and chip manufacturing data were analyzed using a multivariate regression model to determine the most influential manufacturing parameters and steps. In our analysis, we find the amount of sorbent mass present in the chip (variable importance score = 2.6) and heater and the RTD resistance values (variable importance score = 1.1) to be the manufacturing parameters with the greatest impact on chemical performance. Other non-obvious latent manufacturing parameters also had quantified influence. Statistical distributions for each manufacturing step will allow future large-scale production runs to be statistically sampled during production to perform QA/QC in a real-time environment. We report this study as the first data-driven, model-based production of a microfabricated chemical sensor.

Data-Driven Approach to Modeling Microfabricated Chemical Sensor Manufacturing.

Forensic analysis of tetrahydrothiophene (THT) at gas explosion scenes: Adsorption–desorption dynamics on common substrates

Trace chemical detection plays an important role in evaluating environmental hazards as well as benign chemical sources. We have developed a low power dual-polarity ionization-based detector. The detector electronics are operated with a single 9 V battery and provide concentration sensitive voltage outputs. The detection mode can be set manually with the on-board electronics or can be controlled with a microcontroller compatible digital input. The complete assembly and operation of the detector is detailed. The features of the detector make it suitable to be operated as a standalone system or to be integrated as a sub-system into a field-portable analytical platform. The detector can achieve a system step response of ~1.6 s. We performed laboratory measurements with several ionized chemicals using both positive and negative mode. The results showed highly linear responses at trace concentrations as low as 100 ppb. • Low power ion detector with onboard controlled positive and negative mode detection suitable for portable system integration. • Designed with commercially available off-the-shelf (COTS) components and can be operated using a standard 9 V battery. • Designed for low abundance ion detection, suitable for trace chemical VOCs. • As proof of concept, detection of photoionized chemicals at trace levels was performed. 

http://manuscript.elsevier.com/S0924424722000802/pdf/S0924424722000802.pdf

Battery powered dual-polarity ion detector for trace chemical sensing

A device for volatile organic compound (VOC) analysis from skin using heated dynamic headspace sampling.

OpenDMS: An Open-Source Approach to Differential Mobility Spectrometry.

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