Patrick Cras
University of Antwerp
11 Papers
24 Citations
Patrick Cras is an academic researcher from University of Antwerp. The author has contributed to research in topics: Frontotemporal dementia & Frontotemporal lobar degeneration. The author has an hindex of 11, co-authored 11 publications.
Chat about Author
Papers
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.
Ilse Gijselinck,Tim Van Langenhove,Julie van der Zee,Kristel Sleegers,Stéphanie Philtjens,Gernot Kleinberger,Jonathan Janssens,Karolien Bettens,Caroline Van Cauwenberghe,Sandra Pereson,Sebastiaan Engelborghs,Anne Sieben,Anne Sieben,Peter De Jonghe,Rik Vandenberghe,Patrick Santens,Jan De Bleecker,Githa Maes,Veerle Bäumer,Lubina Dillen,Geert Joris,Ivy Cuijt,Ellen Corsmit,Ellen Elinck,Jasper Van Dongen,Steven Vermeulen,Marleen Van den Broeck,Carolien Vaerenberg,Maria Mattheijssens,Karin Peeters,Wim Robberecht,Patrick Cras,Jean-Jacques Martin,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven +35 more
TL;DR: The GGGGCC repeat expansion is highly penetrant, explaining all of the contribution of chromosome 9p21 to FTLD and ALS in the Flanders-Belgian cohort and decreased expression of C9orf72 in brain suggests haploinsufficiency as an underlying disease mechanism.
637
The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter
Ilse Gijselinck,S. Van Mossevelde,J. van der Zee,Anne Sieben,Anne Sieben,Sebastiaan Engelborghs,J. De Bleecker,Adrian Ivanoiu,Olivier Deryck,Dieter Edbauer,Dieter Edbauer,Ming Zhang,Bavo Heeman,Veerle Bäumer,M Van den Broeck,Maria Mattheijssens,K. Peeters,Ekaterina Rogaeva,P. De Jonghe,Patrick Cras,Jean-Jacques Martin,P.P. De Deyn,Marc Cruts,C. Van Broeckhoven +23 more
TL;DR: It is shown that increased methylation of CpGs in the C9orf72 promoter may explain how an increasing G4C2 size lead to loss-of-function without excluding repeat length-dependent toxic gain- of-function.
240
Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia
Elise Cuyvers,Elise Cuyvers,Karolien Bettens,Karolien Bettens,Stéphanie Philtjens,Stéphanie Philtjens,Tim Van Langenhove,Ilse Gijselinck,Ilse Gijselinck,Julie van der Zee,Julie van der Zee,Sebastiaan Engelborghs,Mathieu Vandenbulcke,Jasper Van Dongen,Jasper Van Dongen,Nathalie Geerts,Nathalie Geerts,Githa Maes,Githa Maes,Maria Mattheijssens,Maria Mattheijssens,Karin Peeters,Karin Peeters,Patrick Cras,Rik Vandenberghe,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,Marc Cruts,Marc Cruts,Kristel Sleegers,Kristel Sleegers +31 more
TL;DR: The data corroborate and extend previous findings to include an increased frequency of rare heterozygous TREM2 variations in AD and FTD, and show that T REM2 variants may play a role in neurodegenerative diseases in general.
192
Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort
Ilse Gijselinck,Ilse Gijselinck,Sara Van Mossevelde,Sara Van Mossevelde,Julie van der Zee,Julie van der Zee,Anne Sieben,Stéphanie Philtjens,Stéphanie Philtjens,Bavo Heeman,Bavo Heeman,Sebastiaan Engelborghs,Mathieu Vandenbulcke,Greet De Baets,Veerle Bäumer,Veerle Bäumer,Ivy Cuijt,Ivy Cuijt,Marleen Van den Broeck,Marleen Van den Broeck,Karin Peeters,Karin Peeters,Maria Mattheijssens,Maria Mattheijssens,Frederic Rousseau,Rik Vandenberghe,Peter De Jonghe,Peter De Jonghe,Patrick Cras,Peter Paul De Deyn,Jean-Jacques Martin,Marc Cruts,Marc Cruts,Christine Van Broeckhoven,Christine Van Broeckhoven +34 more
TL;DR: TFD and ALS belong to the same disease continuum, and TBK1 LOF mutations are the third most frequent cause of clinical FTD in the Belgian clinically based patient cohort, after C9orf72 and GRN, and the second most common cause ofclinical ALS after C 9orf72.
Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
Sara Van Mossevelde,Julie van der Zee,Ilse Gijselinck,Sebastiaan Engelborghs,Anne Sieben,Anne Sieben,Tim Van Langenhove,Jan De Bleecker,Jonathan Baets,Mathieu Vandenbulcke,Koen Van Laere,Sarah Ceyssens,Marleen Van den Broeck,Karin Peeters,Maria Mattheijssens,Patrick Cras,Rik Vandenberghe,Peter De Jonghe,Jean-Jacques Martin,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven +21 more
TL;DR: Compared to patients carrying GRN or C9orf72 mutations, differences are seen in age of onset, extrapyramidal symptoms, and in memory, language and behaviour in patients with FTD, ALS or FTD-ALS.
98