Patrick Camilleri
University of Hertfordshire
46 Papers
700 Citations
Patrick Camilleri is an academic researcher from University of Hertfordshire. The author has contributed to research in topics: Capillary electrophoresis & Peptide. The author has an hindex of 18, co-authored 46 publications. Previous affiliations of Patrick Camilleri include The Hertz Corporation.
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Papers
Revisiting the General Solubility Equation: In Silico Prediction of Aqueous Solubility Incorporating the Effect of Topographical Polar Surface Area
TL;DR: An alternative simple model for predicting aqueous solubility is proposed which replaces the melting point descriptor of the GSE with TPSA and hence can be applied to virtual compounds.
233
Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide.
David R. Howlett,Kevin H. Jennings,David C. Lee,Michael S.G. Clark,Frank Brown,Ronald Wetzel,Stephen J. Wood,Patrick Camilleri,Gareth W. Roberts +8 more
TL;DR: The results suggest that the development of neurotoxicity of beta A1-40 is related to the fibrillar state of the peptide.
233
β-Cyclodextrin interacts with the Alzheimer amyloid β-A4 peptide
TL;DR: Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid β‐amyloid peptide (β1‐40) interacts with the cyclic oligosaccharide β‐cyclodextrin, and this interaction has been shown to diminish substantially the neurotoxic effects of β 1‐40 in a cell line.
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In Silico Prediction of Aqueous Solubility Using Simple QSPR Models: The Importance of Phenol and Phenol-like Moieties
TL;DR: Modification of the TPSA model to additionally incorporate a descriptor pertaining to a simple count of phenol and phenol-like moieties improves the predictive ability within ± one log unit, and can be rationalized as the additional descriptor in the model acting as a correction factor which acknowledges the effect of phenolic substituents on the electronic characteristics of aromatic molecules.
88
High resolution and rapid analysis of branched oligosaccharides by capillary electrophoresis.
TL;DR: The fluorophore 2-aminoacridone has been used to label a number of branched oligosaccharides previously released from various glycoproteins and treatment of glycans with N-acetyl neuraminidase provided useful and additional structural information.
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