Patrick Bongen

TL;DR: Genetic engineering of the prodigiosin pathway together with incorporation of synthetic intermediates thus resulted in the formation of a so far unprecedented structural diversity of new prodiginine derivatives in P. putida, which allow reliable conclusions regarding the substrate specificity of PigC, the final condensing enzyme in the Prodigia marcescens biosynthesis pathway.

TL;DR: The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.

TL;DR: 499EST is the first thermoalkalostable esterase derived from a Gram-negative thermoacidophilic bacterium, and exhibits stability under harsh environmental conditions and enantioselectivity towards naproxen and ibuprofen esters, yielding the medically relevant (S)-enantiomers.

TL;DR: An efficient asymmetric synthesis of (S)-2,3-dihydrobenzo[b]furan-3-carboxylic acid and (S), an analgesic agent was established, key to the success was the highly stereoselective enzymatic kinetic resolution of the corresponding methyl or ethyl esters.