Patrick Aldag
Friedrich Loeffler Institute
14 Papers
39 Citations
Patrick Aldag is an academic researcher from Friedrich Loeffler Institute. The author has contributed to research in topics: Reproductive technology & In vitro maturation. The author has an hindex of 7, co-authored 14 publications.
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Papers
Parental genome unification is highly error-prone in mammalian embryos.
Tommaso Cavazza,Yuko Takeda,Antonio Z. Politi,M. Aushev,Patrick Aldag,Clara Baker,Meenakshi Choudhary,Jonas Bucevičius,Gražvydas Lukinavičius,Kay Elder,Martyn Blayney,Andrea Lucas-Hahn,Heiner Niemann,Mary Herbert,Melina Schuh +14 more
TL;DR: This paper showed that the parental genomes cluster with nucleoli in each pronucleus within human and bovine zygotes, and clustering is required for the reliable unification of the parental genome after fertilization.
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Cyclic AMP Affects Oocyte Maturation and Embryo Development in Prepubertal and Adult Cattle
Sandra Milena Bernal-Ulloa,Julia Heinzmann,Doris Herrmann,Klaus-Gerd Hadeler,Patrick Aldag,Sylke Winkler,Dorit Pache,Ulrich Baulain,Andrea Lucas-Hahn,Heiner Niemann +9 more
TL;DR: Data indicate that cAMP regulates IVM in prepubertal and adult oocytes in a similar manner, with impact on the establishment of epigenetic marks and acquisition of full developmental competency.
Extended in vitro maturation affects gene expression and DNA methylation in bovine oocytes
Julia Heinzmann,Felix Mattern,Patrick Aldag,Sandra Milena Bernal-Ulloa,Tamara Schneider,Thomas Haaf,Heiner Niemann +6 more
TL;DR: The results indicate that extended IVM leads to ageing-like alterations and demonstrate that epigenetic mechanisms are critically involved in ageing of bovine oocytes, which warrants further studies into epigenetic mechanism involved in Ageing of female germ cells, including humans.
Melatonin enhances in vitro developmental competence of cumulus-oocyte complexes collected by ovum pick-up in prepubertal and adult dairy cattle.
Juan Carlos Gutiérrez-Añez,Andrea Lucas-Hahn,Klaus-Gerd Hadeler,Patrick Aldag,Heiner Niemann +4 more
TL;DR: It is indicated that the presence of melatonin during in vitro maturation improves cumulus-oocyte competence, embryo development, and quality by increasing the allocation of embryonic cells to the ICM compartment and the total number of embryos cells in both adult and prepubertal bovine donors.
20
Melatonin improves rate of monospermic fertilization and early embryo development in a bovine IVF system.
Juan Carlos Gutiérrez-Añez,Juan Carlos Gutiérrez-Añez,Heiko Henning,Andrea Lucas-Hahn,Ulrich Baulain,Patrick Aldag,Birgit Sieg,Vivian Hensel,Doris Herrmann,Heiner Niemann +9 more
TL;DR: In this paper, the effects of melatonin on post-thaw sperm quality, fertilizing ability, and embryo development and competence in vitro after in vitro fertilization were evaluated.