Patricia H. Janak
Johns Hopkins University
159 Papers
2K Citations
Patricia H. Janak is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nucleus accumbens & Ventral tegmental area. The author has an hindex of 60, co-authored 147 publications. Previous affiliations of Patricia H. Janak include University of North Carolina at Chapel Hill & University of Lausanne.
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Papers
Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens.
Elizabeth E. Steinberg,Josiah R. Boivin,Benjamin T. Saunders,Ilana B. Witten,Karl Deisseroth,Patricia H. Janak +5 more
TL;DR: Transgenic rats are examined in transgenic rats to demonstrate that the NAc is a critical efferent target sustaining dopamine neuron-specific ICSS, identify receptor subtypes through which dopamine acts to promote this behavior, and ultimately help to refine the understanding of the neural circuitry mediating positive reinforcement.
Dorsomedial striatal activity tracks completion of behavioral sequences
Youna Vandaele,David J. Ottenheimer,David J. Ottenheimer,Patricia H. Janak,Patricia H. Janak +4 more
TL;DR: This work examines how dorsomedial striatum (DMS), a region pivotal for forming associations among stimuli, actions, and outcomes, encodes the execution of goal-directed action sequences that require self-monitoring of behavior.
Long-range orbitofrontal and amygdala axons show divergent patterns of maturation in the frontal cortex across adolescence.
Carolyn M. Johnson,Carolyn M. Johnson,Carolyn M. Johnson,F. Alexandra Loucks,Hannah Peckler,A. Wren Thomas,Patricia H. Janak,Linda Wilbrecht +7 more
TL;DR: Time-lapse observations of long-range axons that innervate the frontal cortex in the living brain reveal projection specific maturation of synaptic structures within a single frontal region and suggest that stabilization is a more general characteristic of maturation than pruning.
Decreases in Cued Reward Seeking After Reward-Paired Inhibition of Mesolimbic Dopamine.
TL;DR: Findings suggest changes in mesolimbic dopaminergic transmission at the time of experienced reward impacts subsequent responding to cues in well-trained subjects as predicted for a learning signal.
α4-Containing GABAA Receptors in the Nucleus Accumbens Mediate Moderate Intake of Alcohol
TL;DR: Evidence is provided that an α4-subunit-containing GABAA receptor contributes to the consumption of low-to-moderate levels of alcohol and reduced expression of the α4 subunit in the nucleus accumbens (NAc) shell of rats decreased their free consumption of and preference for alcohol.