Patricia H. Janak
Johns Hopkins University
159 Papers
2K Citations
Patricia H. Janak is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nucleus accumbens & Ventral tegmental area. The author has an hindex of 60, co-authored 147 publications. Previous affiliations of Patricia H. Janak include University of North Carolina at Chapel Hill & University of Lausanne.
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Papers
Microinjection of Glycine into the Ventral Tegmental Area Selectively Decreases Ethanol Consumption
TL;DR: It is found that the infusion of glycine into the VTA selectively reduced the intake of ethanol but not sucrose or water in rats chronically exposed to ethanol under the intermittent-access and continuous-access procedures and decreased lever-press responding for ethanol under an operant self-administration procedure.
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Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons
Rong Mao,Rong Mao,Damon T. Page,Damon T. Page,Irina Merzlyak,Carol Kim,Laurence H. Tecott,Patricia H. Janak,John L.R. Rubenstein,Mriganka Sur,Mriganka Sur +10 more
TL;DR: A critical role is demonstrated for the Dlx1 gene, and likely the subclasses of interneurons that are affected by the lack of this gene, in behavioral inhibition and associative fear learning, and the involvement of particular components of the GABAergic system in specific behavioral phenotypes related to complex neuropsychiatric diseases.
The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options.
TL;DR: Repeating the OFC inactivation before the reversal memory test restored normal behavior, confirming the hypothesis of a dominant impact of OFC on other decision-making circuits and suggesting a potential conflict between OFC (encoded pre-reversal contingencies) and other brain circuits (encoding the new contingencies).
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Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction.
Joo Han Lee,Efrain Ribeiro,Jeongseop Kim,Bumjin Ko,Hope Kronman,Yun Ha Jeong,Jong Kyoung Kim,Patricia H. Janak,Eric J. Nestler,Ja Wook Koo,Joung Hun Kim +10 more
TL;DR: These findings provide a molecular mechanism for dopaminergic control of NAc ChINs that can control the susceptibility to cocaine-seeking behavior.
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changes in the influence of alcohol-Paired stimuli on alcohol seeking across extended Training
TL;DR: The data indicate that reward–predictive stimuli have a stronger contribution to responding after extended training, which provides insight into the factors that control behavior after extended drug use.