Patricia D. Wilson
University College London
133 Papers
1.4K Citations
Patricia D. Wilson is an academic researcher from University College London. The author has contributed to research in topics: Autosomal dominant polycystic kidney disease & Kidney. The author has an hindex of 48, co-authored 132 publications. Previous affiliations of Patricia D. Wilson include Johns Hopkins University School of Medicine & National Institutes of Health.
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Papers
A role for CFTR in human autosomal dominant polycystic kidney disease.
TL;DR: Data indicate that the CFTR Cl- channel exists in apical membranes of ADPKD cells and may play an important role in cyst formation or enlargement.
Polycystic kidney disease.
TL;DR: The clinical importance of polycystic kidney diseases is outlined and the cell biology and molecular mechanisms that cause the formation of hundreds of cystic lesions in the renal parenchyma are discussed.
Adhesion Molecules in Renal Disease
Peter Mundel,Stuart J. Shankland,Michael A. Horton,Stephen Hart,Felicitas Pröls,Andrea Hartner,Harald O. Schöcklmann,R. Bernd Sterzel,Jill T. Norman,Leon G. Fine,Alexander R. Rosenkranz,Tanya N. Mayadas,Patricia D. Wilson,Christopher R. Burrow,Agnes B. Fogo,Duska Dragun,Hermann Haller,Alan O. Perantoni,Susan R. Rittling,David T. Denhardt +19 more
ATP Release Mechanisms in Primary Cultures of Epithelia Derived from the Cysts of Polycystic Kidneys
TL;DR: Test results show that ADPKD and non-ADPKD human epithelial primary cultures release ATP under basal and stimulated conditions and that ATP is released in vitro and into the cyst fluid by cystic epithelial cells in concentrations sufficient to stimulate ATP receptors.
Transduction of Renal Cells in Vitro and in Vivo by Adeno-Associated Virus Gene Therapy Vectors
Michael S. Lipkowitz,Basil Hanss,Natalie Tulchin,Patricia D. Wilson,Jessica C. Langer,Michael W. Ross,Gary J. Kurtzman,Paul E. Klotman,Mary E. Klotman +8 more
TL;DR: It is shown that AAV can deliver reporter genes with approximately equal efficiency to human mesangial, proximal tubule, thick ascending limb, collecting tubules, and renal cell carcinoma cells in primary culture and can be a useful tool for renal gene delivery.