Patricia D. Wilson
University College London
133 Papers
1.4K Citations
Patricia D. Wilson is an academic researcher from University College London. The author has contributed to research in topics: Autosomal dominant polycystic kidney disease & Kidney. The author has an hindex of 48, co-authored 132 publications. Previous affiliations of Patricia D. Wilson include Johns Hopkins University School of Medicine & National Institutes of Health.
Chat about Author
Papers
Expression of CFTR in human and bovine thyroid epithelium.
Olivier Devuyst,Philippe Golstein,Marcio V. Sanches,Klaus Piontek,Patricia D. Wilson,William B. Guggino,Jacques E. Dumont,Renaud Beauwens +7 more
TL;DR: The expression of CFTR at the mRNA and protein levels in human and bovine thyroid follicular cells are demonstrated and suggested that CFTR expression could be instrumental in follicular enlargement.
Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity
Jingjing Zhang,Maoqing Wu,Shixuan Wang,Jagesh V. Shah,Patricia D. Wilson,Patricia D. Wilson,Jing Zhou +6 more
TL;DR: A novel function of FPC is demonstrated in centrosome duplication and mitotic spindle assembly during cell division in ARPKD and it is proposed that mitotic defects due to FPC dysfunction contribute to cystogenesis in AR PKD.
Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease
Olivier Devuyst,Christopher R. Burrow,Barbara L. Smith,Peter Agre,Mark A. Knepper,Patricia D. Wilson +5 more
TL;DR: Specific, mutually exclusive localization of AQP1 and AQP2 in human fetal and adult kidneys is demonstrated and shows that both channels are expressed early during nephrogenesis, and that the mutual exclusivity of localization is maintained even into end-stage ADPKD.
Heterologous Expression and Functional Characterization of a Mouse Renal Organic Anion Transporter in Mammalian Cells
TL;DR: It is concluded that COS-7 cells may be useful in pharmacological and molecular biological studies of this carrier, as the carbohydrate moieties are necessary for the proper trafficking of mOAT to the plasma membrane, and histidine residues appear to be important for the transport function.
Apical Plasma Membrane Mispolarization of NaK-ATPase in Polycystic Kidney Disease Epithelia Is Associated with Aberrant Expression of the β2 Isoform
Patricia D. Wilson,Olivier Devuyst,Xiaohong Li,Laura Gatti,Doris Falkenstein,Shawn W. Robinson,Douglas M. Fambrough,Christopher R. Burrow +7 more
TL;DR: Western blot analysis and immunocytochemical studies showed that, in normal adult kidneys, peptide subunit-specific antibodies against alpha1 and beta1 localized to the basolateral membranes of normal renal tubules, predominantly thick ascending limbs of Henle's loop.