Synthesis and anticancer activity of long chain substituted 1,3,4-oxadiazol-2-thione, 1,2,4-triazol-3-thione and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives

In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by "click" chemistry.

/pdf/amidoximes-applications-and-methods-of-synthesis-2po02nu4xp.pdf

Amidoximes: Applications and Methods of Synthesis

This research is for academic understanding to work out new ligand behavior4-({(5-(4-hydroxyphenyl)-3-sulfanyl-1H-1,2,4-triazol-1-yl)amino}(1H-tetrazol-5-yl)methyl)-2-methoxyphenol (L) with gold (III) and nickel (II) metal ions. Ligand (L) has been synthesized from cyclization of the interaction of (4-hydroxy-3-methoxyphenyl){[5-(4-hydroxyphenyl)-3-sulfanyl-1H-1,2,4-triazol-1-yl]amino}acetonitrile (F) with sodium azide. α-Amino nitrile compound (F) intern synthesized from interaction of aldehyde amine and KCN acidic medium as three components one put reaction. The presence of well oriented donor atoms (N2-type) of ligand (L) interacted with gold (III) and nickel (II) ions under reflux to prepare [1:2] [M:L]Cl electrolytic complexes, the complexes [Au (L)3]Cl3and [Ni (L)2]Cl2were suggested to have square planar geometry. The resulting products were characterized via technical1H-NMR, UV-Vis, IR spectroscopy, conductivity and EDX. The cytotoxic effect was studied on a breast cancer cell line (MCF-7 cell line). At different concentrations for both complexes. The results showed that gold(III) complex has higher cytotoxicity than nickel(II) complex against cancer cell line.

Synthesis, Characterization and Anti-Cancer Activity of gold (III) and Nickel (II) Metal Ion Complexes Derived from Tetrazole-Triazole Compound

Azole-based organometallic compounds as bioactive agents

Azol e s belong to very important class of Antimicrobial drugs. Triazole is very important Azole which e xist s in two isomeric form s namely 1 , 2, 3 - Triazole and 1 , 2, 4 - Triazole. This Review Article covers the Different approaches to synthesize Triazole s having different substitution and their different biological activity. This Review article can be use ful t o synthesize n ew compounds having Triazole nucleolus.

/pdf/triaz-ole-a-potential-bioactive-agent-s-ynth-e-sis-and-33rpqv6squ.pdf

Triaz ole : a potential bioactive agent (s ynth e sis and biological activity)

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Triaz ole : a potential bioactive agent (s ynth e sis and biological activity)