Patcharee Ritprajak
Harvard University
3 Papers
14 Citations
Patcharee Ritprajak is an academic researcher from Harvard University. The author has contributed to research in topics: ZAP70 & MAP kinase kinase kinase. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Patcharee Ritprajak include Chulalongkorn University.
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Papers
Tuning of Protein Kinase Circuitry by p38α Is Vital for Epithelial Tissue Homeostasis
Celia Caballero-Franco,Min-Kyung Choo,Yasuyo Sano,Patcharee Ritprajak,Patcharee Ritprajak,Hiroaki Sakurai,Kinya Otsu,Kinya Otsu,Atsushi Mizoguchi,Jin Mo Park +9 more
TL;DR: It is found that epithelial-specific loss of the protein kinase p38α leads to aberrant activation of TAK1, JNK, EGF receptor, and ERK in distinct microanatomical areas of the intestines and skin and provides clues about how to prevent the adverse effects of p38 inhibitors.
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Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
Morisada Hayakawa,Morisada Hayakawa,Hiroko Hayakawa,Hiroko Hayakawa,Tsvetana Petrova,Patcharee Ritprajak,Patcharee Ritprajak,Ruhcha V. Sutavani,Guillermina Yanek Jiménez-Andrade,Yasuyo Sano,Min-Kyung Choo,John Seavitt,Ram K C Venigalla,Kinya Otsu,Katia Georgopoulos,J. Simon C. Arthur,Jin Mo Park +16 more
TL;DR: Double deficiency of p38α and p38β in naïve CD4+ T cells resulted in an attenuation of MAPK-activated protein kinase (MK)-dependent mTOR signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease
TL;DR: It is shown that the effect of interfering with p38α signaling can be therapeutic or adverse depending on the targeted cell type, and cell-selective targeting is suggested as a potential solution for improving their therapeutic index.