Pascal Y. Smith
Laval University
11 Papers
8 Citations
Pascal Y. Smith is an academic researcher from Laval University. The author has contributed to research in topics: Regulation of gene expression & Tau protein. The author has an hindex of 8, co-authored 11 publications.
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Papers
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
Sébastien S. Hébert,Sébastien S. Hébert,Aikaterini S. Papadopoulou,Pascal Y. Smith,Marie-Christine Galas,Marie-Christine Galas,Emmanuel Planel,Asli Silahtaroglu,Nicolas Sergeant,Nicolas Sergeant,Luc Buée,Luc Buée,Bart De Strooper +12 more
TL;DR: The hypothesis that changes in the miRNA network may contribute to a neurodegenerative phenotype by affecting tau phosphorylation is supported.
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miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
Pascal Y. Smith,Julia Hernandez-Rapp,Francis Jolivette,Cynthia Lecours,Kanchan Bisht,Claudia Goupil,Véronique Dorval,Sepideh Parsi,Françoise Morin,Emmanuel Planel,David A. Bennett,Francisco-Jose Fernandez-Gomez,Nicolas Sergeant,Luc Buée,Marie-Ève Tremblay,Frédéric Calon,Sébastien S. Hébert +16 more
TL;DR: A role for miR-132/212 in the regulation of tau pathology in mice and humans is supported and new alternatives for therapeutic development are provided.
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
TL;DR: In this article, it was shown that miRNAs are equally involved in the regulation of neuronal amyloid precursor protein (APP) alternative splicing in Alzheimer's disease, while ectopic expression of miR-124, an abundant neuronal-specific miRNA, reversed these effects.
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MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy
Pascal Y. Smith,Charlotte Delay,Johanne Girard,Marie-Amélie Papon,Emmanuel Planel,Nicolas Sergeant,Nicolas Sergeant,Luc Buée,Luc Buée,Sébastien S. Hébert +9 more
TL;DR: Results suggest that changes in the miR-132/PTBP2 pathway could contribute to the abnormal splicing of tau exon 10 in the brain, and sheds light into the potential role played by miRNAs in a subset of tAUopathies.
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microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice.
Julia Hernandez-Rapp,Sara Rainone,Claudia Goupil,Véronique Dorval,Pascal Y. Smith,Martine Saint-Pierre,Maxime Vallée,Emmanuel Planel,Arnaud Droit,Frédéric Calon,Francesca Cicchetti,Sébastien S. Hébert +11 more
TL;DR: The results support the hypothesis that the miR-132/212 network, including Sirt1 and likely other target genes, contributes to abnormal Aβ metabolism and senile plaque deposition in AD and opens the door to multifactorial drug targets of AD by targeting Aβ and Tau.
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