Pascal Syren
University Hospital Heidelberg
7 Papers
6 Citations
Pascal Syren is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Heart failure & Atrial fibrillation. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Pascal Syren include Heidelberg University & Lund University.
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Papers
TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.
Patrick Lugenbiel,Fabian Wenz,Pascal Syren,Pascal Geschwill,Katharina Govorov,Claudia Seyler,Derk Frank,Patrick A. Schweizer,Jennifer Franke,Tanja Weis,Claus Bruehl,Bastian Schmack,Arjang Ruhparwar,Matthias Karck,Norbert Frey,Hugo A. Katus,Dierk Thomas +16 more
TL;DR: Mechanistic and potential therapeutic significance of TREK-1 channels are suggested in a subgroup of AF patients with HF and prolonged atrial effective refractory periods, consistent with prior observations in humans with HF.
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Epigenetic Alterations as Biomarkers in Pancreatic Ductal Adenocarcinoma
TL;DR: No single epigenetic biomarker that offers a sufficient specificity has been discovered yet, but patterns containing multiple independent biomarkers exist.
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Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes.
Patrick Lugenbiel,Katharina Govorov,Ann-Kathrin Rahm,Teresa Wieder,Dominik Gramlich,Pascal Syren,Nadine Weiberg,Claudia Seyler,Claudia Seyler,Hugo A. Katus,Hugo A. Katus,Dierk Thomas,Dierk Thomas +12 more
TL;DR: The present findings link class I/II HDAC activity to regulation of ion channel expression and action potential duration in atrial cardiomyocytes and clinical implications for HDAC-based antiarrhythmic therapy and cardiac safety of HDAC inhibitors require further investigation.
Atrial myofibroblast activation and connective tissue formation in a porcine model of atrial fibrillation and reduced left ventricular function.
Patrick Lugenbiel,Fabian Wenz,Katharina Govorov,Pascal Syren,Hugo A. Katus,Dierk Thomas,Dierk Thomas +6 more
TL;DR: AF was associated with atrial dilation, increased atrial fibrosis, and enhanced expression of collagens I and V in right atrial tissue after 14 days follow‐up, and Prevention of fibroblast‐to‐myofibroblast switching may serve as target for remodeling‐based antiarrhythmic AF therapy.
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Electrical Ventricular Remodeling in Dilated Cardiomyopathy.
Christine Mages,Heike Gampp,Pascal Syren,Ann-Kathrin Rahm,Florian Andre,Norbert Frey,Patrick Lugenbiel,Dierk Thomas +7 more
TL;DR: In this paper, a review summarizes clinical and cellular electrophysiologic characteristics observed in dilated cardiomyopathy (DCM) with ionic and structural alterations at the ventricular level.
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