Pascal Sommer
Centre national de la recherche scientifique
40 Papers
413 Citations
Pascal Sommer is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Lysyl oxidase & Elastin. The author has an hindex of 21, co-authored 38 publications. Previous affiliations of Pascal Sommer include University of Lyon.
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Papers
The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Floriane Pez,Frédéric Dayan,Jérôme Durivault,Bastien Kaniewski,Géraldine Aimond,Gabrielle S. Le Provost,Blandine Deux,Philippe Clézardin,Pascal Sommer,Jacques Pouysségur,Caroline Reynaud +10 more
TL;DR: Mechanistic investigations revealed that LOX activated the PI3K (phosphoinositide 3-kinase)-Akt signaling pathway, thereby upregulating HIF-1α protein synthesis in a manner requiring LOX-mediated hydrogen peroxide production, suggesting that Hif-1/LOX mutual regulation is a pivotal mechanism in the adaptation of tumor cells to hypoxia.
175
Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers.
Emmanuelle Noblesse,Valerie Cenizo,Charbel Bouez,Agnès Borel,Claudine Gleyzal,Simone Peyrol,Marie-Paule Jacob,Pascal Sommer,Odile Damour +8 more
TL;DR: Data favor a role for LOXL in elastic fiber formation, together with LOX, and within the epidermis where both enzymes should play a role in post-translational modification of yet unknown substrates.
103
LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression.
TL;DR: LOXL can be considered as a new target to reinduce elastogenesis at the adult age, because its stimulation by a dill extract is correlated with increased elastin detection, suggesting an increase inElastogenesis efficiency.
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Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta.
TL;DR: Findings indicate a different spatial and temporal expression of LOX and LOXL1 during growth and aging in the rat aorta and suggest specific roles forLOX andLOXL1 in the synthesis and remodeling of elastic and collagen fibers.
71
The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model
Charbel Bouez,Caroline Reynaud,Emmanuelle Noblesse,Amélie Thépot,Claudine Gleyzal,Jean Kanitakis,Eric Perrier,Odile Damour,Pascal Sommer +8 more
TL;DR: Results clearly indicate that lysyl oxidase enzymatic activity is essential not only for the integrity maintenance of the dermis but also for the homeostasis of the epidermis.
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