Pascal Schorr
Saarland University
7 Papers
Pascal Schorr is an academic researcher from Saarland University. The author has contributed to research in topics: Mass spectrometry & Chemistry. The author has an hindex of 4, co-authored 4 publications.
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Papers
Decay Mechanisms of Protonated 4-Quinolone Antibiotics After Electrospray Ionization and Ion Activation
TL;DR: An experimental comparison and theoretical treatment of factors influencing the formation ratio of the charge isomers during ESI, including solvent pH, protic/aprotic nature of solvent, and structural effects such as pKa and proton affinity are provided.
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Comparing derivatization reagents for quantitative LC–MS/MS analysis of a variety of vitamin D metabolites
TL;DR: In this article , the authors compared the sensitivity and selectivity of the analysis of multiple vitamin D metabolites after chemical derivatization using different reagents for liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Differentiation of Dihydroxylated Vitamin D3 Isomers Using Tandem Mass Spectrometry
Anisha Haris,Yuko P. Y. Lam,Christopher A. Wootton,Alina Theisen,Bryan P. Marzullo,Pascal Schorr,Dietrich A. Volmer,Peter B. O’Connor +7 more
TL;DR: Fragments generated due to cleavage of the C-6/C-7 bond in the 1,25-dihydroxyvitamin D3 compound demonstrate that the fragile OH groups were retained during fragmentation, thus enabling differentiation between the two dihydroxylated vitamin D3 isomers without the need for prior chromatographic separation or derivatization.
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Improved quantitative LC-MS/MS analysis of vitamin D metabolites in serum after one-pot double derivatization.
TL;DR: In this article , a one-pot double derivatization scheme was proposed to improve separation efficiency and provide baseline separations of the five vitamin D metabolites 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), 24,25dihdioxydioxynopyridine-3,5-dione (24,25DioxynOPyridine), 3β-25-hydroxyv vitamin D3(3α-25)-D3, and vitamin D-3 on a C-18 stationary phase.
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A simple micro-extraction plate assay for automated LC-MS/MS analysis of human serum 25-hydroxyvitamin D levels.
TL;DR: This short application note describes a simple and automated assay for determination of 25-hydroxyvitamin D levels in very small volumes of human serum that can be rapidly established in non-specialized laboratories within days, without the need for laborious and time consuming sample preparation steps, advanced calibration or data acquisition routines.