Pascal Dube
Pfizer
38 Papers
145 Citations
Pascal Dube is an academic researcher from Pfizer. The author has contributed to research in topics: Catalysis & Borane. The author has an hindex of 16, co-authored 36 publications. Previous affiliations of Pascal Dube include Merck & Co. & Université de Sherbrooke.
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Papers
Synthesis of benzonorcaradienes by gold(I)-catalyzed [4+3] annulation.
TL;DR: A formal [4 + 3]-annulation of vinyl arenes and diynyl propargyl esters is described and a mechanism involving cationic phosphinegold(I)-catalyzed tandem cyclopropanation/hydroarylation to produce the benzonorcaradiene products is proposed.
Promising CL‐20‐Based Energetic Material by Cocrystallization
Stephen R. Anderson,Pascal Dube,Mariusz Krawiec,Jerry S. Salan,David J. am Ende,Philip Samuels +5 more
TL;DR: In this paper, a novel cocrystal (NEX-1) of CL-20 and MDNT is presented, obtained in high yield by resonant acoustic mixing, showing new properties versus the discrete components.
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Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin
Paul Bowles,Steven J. Brenek,Stephane Caron,Nga M. Do,Michele T. Drexler,Shengquan Duan,Pascal Dube,Eric C. Hansen,Brian P. Jones,Kris N. Jones,Tomislav A. Ljubicic,Teresa W. Makowski,Jason Mustakis,Jade D. Nelson,Mark Olivier,Zhihui Peng,Hahdi H. Perfect,David Place,John A. Ragan,John J. Salisbury,Corey L. Stanchina,Brian C. Vanderplas,Mark E. Webster,R. Matt Weekly +23 more
TL;DR: A practical synthesis of SGLT2 inhibitor candidate ertugliflozin has been developed for potential commercial application and high chemical purity of the API is assured through isolation of the crystalline penultimate intermediate, tetraacetate 39.
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The use of borane–amine adducts as versatile palladium-catalyzed hydrogen-transfer reagents in methanol
Michel Couturier,Brian M. Andresen,John L. Tucker,Pascal Dube,Steven J. Brenek,Joanna Teresa Negri +5 more
TL;DR: In this article, the scope of borane-amine adducts as reducing agents is broadened through palladium-catalyzed methanolysis capable of reducing a wide variety of functional groups.
36
Synthesis and reactivity of N-hydroxy-2-aminoindoles
Michel Belley,Effiette L. O. Sauer,Daniel Beaudoin,Petar Duspara,Laird A. Trimble,Pascal Dube +5 more
TL;DR: In this article, a catalytic hydrogenation of (2-nitrophenyl)acetonitriles bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph 3 P) 4 Pd, affords N -hydroxy-2-aminoindoles in good to excellent yields.
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