Pascal Detampel
University of Calgary
5 Papers
Pascal Detampel is an academic researcher from University of Calgary. The author has contributed to research in topics: Chemistry & Antigen processing. The author has an hindex of 5, co-authored 5 publications.
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Papers
Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices
Santiswarup Singha,Kun Shao,Yang Yang,Xavier Clemente-Casares,Patricia Solé,Antonio Clemente,Jesús Blanco,Qin Dai,Fayi Song,Shang Wan Liu,Jun Yamanouchi,Channakeshava Sokke Umeshappa,Roopa Hebbandi Nanjundappa,Pascal Detampel,Matthias Amrein,César Fandos,Robert L. Tanguay,Susan Newbigging,Pau Serra,Anmar Khadra,Warren C. W. Chan,Pere Santamaria +21 more
TL;DR: The engineering principles impacting biological activity are defined, a synthesis process yielding safe and stable compounds are detailed, and how these nanomedicines interact with cognate T cells are visualize.
138
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact
Aswin Hari,Yifei Zhang,Zhongyuan Tu,Pascal Detampel,Melanie D. Stenner,Anutosh Ganguly,Yan Shi +6 more
TL;DR: It is provided evidence to suggest that macrophage cell membrane binding to immobilized crystals was sufficient to induce IL-1β release, and this activation of the NLRP3 inflammasome was inhibited by blocking potassium efflux.
Redirecting soluble antigen for MHC class I cross‐presentation during phagocytosis
Aswin Hari,Anutosh Ganguly,Libing Mu,Shevaun P. Davis,Melanie D. Stenner,Raymond Lam,Fay Munro,Inana Namet,Enaam Alghamdi,Tobias Fürstenhaupt,Wei Dong,Pascal Detampel,Lian Jun Shen,Matthias Amrein,Robin M. Yates,Yan Shi,Yan Shi +16 more
TL;DR: It is reported that mouse dendritic cell engagement to a phagocytic target alters endocytic processing and inhibits the proteolytic activities, and external soluble antigens are targeted into the MHC class I cross‐presentation pathway.
39
In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
Pascal Detampel,Anutosh Ganguly,Anutosh Ganguly,Sara Tehranian,Francis H. Y. Green,Santiswarup Singha,Pere Santamaria,Ayodeji Jeje,Clifford S. Cho,Björn Petri,Matthias Amrein +10 more
TL;DR: A novel, highly effective pathway for the particles to cross the alveolar epithelium and reach the lymph and bloodstream is described, consistent with published kinetic studies in rats and mice.
31
Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy.
Jiahuan Chen,Anutosh Ganguly,Ashley D. Mucsi,Junchen Meng,Jiacong Yan,Pascal Detampel,Fay Munro,Zongde Zhang,Mei Wu,Aswin Hari,Melanie D. Stenner,Wencheng Zheng,Paul Kubes,Tie Xia,Matthias Amrein,Hai Qi,Yan Shi +16 more
TL;DR: A dynamic cytoskeletal component underlying T reg cell–mediated DC suppression in a contact-dependent manner is revealed, which causes a lethargic state of DCs, leading to reduced T cell priming.