Pascal Bernatchez
Yale University
8 Papers
1 Citations
Pascal Bernatchez is an academic researcher from Yale University. The author has contributed to research in topics: Caveolae & Endothelial stem cell. The author has an hindex of 6, co-authored 8 publications.
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Papers
Caveolae and Caveolins in the Cardiovascular System
TL;DR: New insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.
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Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
Carlos Fernández-Hernando,Masaki Fukata,Pascal Bernatchez,Yuko Fukata,Michelle I. Lin,David S. Bredt,William C. Sessa +6 more
TL;DR: Five new Golgi-targeted DHHC enzymes in human endothelial cells are described and a regulatory role of DHHC-21 in governing eNOS localization and function is suggested.
Endothelial-Specific Expression of Mitochondrial Thioredoxin Improves Endothelial Cell Function and Reduces Atherosclerotic Lesions
Haifeng Zhang,Yan Luo,Yan Luo,Wei Zhang,Wei Zhang,Yun He,Shengchuan Dai,Rong Zhang,Yan Huang,Pascal Bernatchez,Frank J. Giordano,Gerald S. Shadel,William C. Sessa,Wang Min +13 more
TL;DR: The role of the mitochondrial antioxidant system thioredoxin (Trx2) in vasculature is not understood by using endothelial cell (EC)-specific transgenesis of the mitochondria form of the thIoredoxin gene in mice (trx2 TG) as mentioned in this paper.
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Endothelial Caveolin-1 Regulates Pathologic Angiogenesis in a Mouse Model of Colitis
John H. Chidlow,Joshua J.M. Greer,Christoph Anthoni,Pascal Bernatchez,Carlos Fernadez–Hernando,Megan Bruce,Maisoun Abdelbaqi,Deepti Shukla,D. Neil Granger,William C. Sessa,Christopher G. Kevil +10 more
TL;DR: Modulation of Cav-1 could provide a novel therapeutic target for IBD because it mediates angiogenesis in experimental colitis and is the critical regulator of colitis.
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Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis.
Vishal C Mehra,Elias Jackson,Xian M. Zhang,Xian Cheng Jiang,Lawrence W. Dobrucki,Jun Yu,Pascal Bernatchez,Albert J. Sinusas,Gerald I. Shulman,William C. Sessa,Timur O. Yarovinsky,Jeffrey R. Bender +11 more
TL;DR: An endothelial VEGF resistance mechanism conferred by PA is demonstrated, which comprises ceramide-induced, PP2A-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.
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