Pascal Barneoud
Rhône-Poulenc
27 Papers
645 Citations
Pascal Barneoud is an academic researcher from Rhône-Poulenc. The author has contributed to research in topics: Dopaminergic & Blood–brain barrier. The author has an hindex of 13, co-authored 27 publications.
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Papers
Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
Philippe Horellou,Emmanuelle Vigne,Marie-Noëlle Castel,Pascal Barneoud,Philippe Colin,Michel Perricaudet,Pia Delaere,Jacques Mallet +7 more
TL;DR: A recombinant adenovirus encoding tyrosine hydroxylase was constructed, and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats, causing a rotation asymmetry induced by apomorphine.
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Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area.
TL;DR: Results demonstrate the selective localisation of a number of nAChR subunit mRNA within dopaminergic neurons, strongly suggesting that a heterogenous population of n AChRs play a role in modulating dopaminergy neuronal activity.
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Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system.
TL;DR: The paw‐reaching impairments resulting from the partial striatal denervation are proposed as a model of the early symptoms of Parkinson's disease and may be useful for the development of restorative therapies.
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Quantitative motor assessment in FALS mice: a longitudinal study.
TL;DR: Transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly93→Ala) presents changes in motor function reminiscent of the human disease, reinforcing and extending its validity as an animal model of familial amyotrophic lateral sclerosis (FALS) and allowing the investigation of novel drug treatment for ALS.
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NF-L in cerebrospinal fluid and serum is a biomarker of neuronal damage in an inducible mouse model of neurodegeneration
Anthony Brureau,Véronique Blanchard-Bregeon,Catherine Pech,Stephanie Hamon,Pascal Chaillou,Jean-Claude Guillemot,Pascal Barneoud,Philippe Bertrand,Laurent Pradier,Thomas Rooney,Nathalie Schussler +10 more
TL;DR: The results suggest that CSF and serum NF-L are of interest to be further explored as potential translational dynamic biomarkers of neurodegeneration or as pharmacodynamics biomarkers at least in preclinical animal studies.
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