Parkash Jhurani
Genentech
11 Papers
186 Citations
Parkash Jhurani is an academic researcher from Genentech. The author has contributed to research in topics: Fusion protein & Oligonucleotide. The author has an hindex of 7, co-authored 11 publications.
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Papers
Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis
TL;DR: Three discontinuous polypeptide determinants in hGH--the loop between residues 54 and 74, the central portion of helix 4 to the carboxyl terminus, and to a lesser extent the amino-terminal region ofhelix 1--modulate binding to the liver receptor.
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High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.
Frederic A. Fellouse,Kaori Esaki,Sara C. Birtalan,Demetrios Raptis,Vincenzo J. Cancasci,Akiko Koide,Parkash Jhurani,Mark Vasser,Christian Wiesmann,Anthony A. Kossiakoff,Shohei Koide,Sachdev S. Sidhu +11 more
TL;DR: This fully synthetic, minimalist library has essentially recapitulated the capacity of the natural immune system to generate high-affinity antibodies by systematically augmented the original binary library with additional levels of diversity and examined the effects.
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Production of biologically active N alpha-desacetylthymosin alpha 1 in Escherichia coli through expression of a chemically synthesized gene.
Ronald Wetzel,Herbert L. Heyneker,David V. Goeddel,Parkash Jhurani,Joel Shapiro,Roberto Crea,Teresa L. K. Low,John E. McClure,Gary B. Thurman,Allan L. Goldstein +9 more
TL;DR: Results of a guinea pig migration inhibition factor assay, a terminal deoxyribonucleotidyl transferase (TdT) assay, and radioimmunoassay indicate that the N alpha-desacetylthymosin alpha 1 produced by deoxy ribonucleic acid (DNA) cloning techniques has biological activity equivalent to that of the native hormone.
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Distinct Molecular Phenotypes in Murine Cardiac Muscle Development, Growth, and Hypertrophy
Jill Schoenfeld,Mark Vasser,Parkash Jhurani,Peter Ng,John J. Hunter,John Ross,Kenneth R. Chien,David G. Lowe +7 more
TL;DR: The first gene expression profile of the murine myocardium is reported, using a rapid method of quantitative expression analysis based on real-time analytical RT-PCR, suggesting that the response to POL involves a subset of re-expressed developmental genes together with altered expression of genes not necessarily associated with cardiac development.
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