Anti-inflammatory activity of the extracts of ginseng berry (GBE) was investigated through the evaluation of its inhibitory effect on the production of inflammatory meditator, nitric oxide(NO), tumor necrocis factor-alpha (TNF-α), interleukin-6 (IL-6) in LPS-induced RAW264.7 macrophage cells. GBE was fractionated using n-hexane, chloroform, ethy- lacetate, buthanol and H2O, sequentially. RAW264.7 cells were induced 100 ng/㎖ of lipopolysaccharide (LPS) and treated with 0, 1.6, 8, 40 and 200 ㎍/㎖ of GBE fractions. LPS-induced NO production on all of GBE fractions was inhibited with increasing added concentration of GBE fractions. Chloroform fraction of GBE was the most effective in inhibiting LPS- induced TNF-α production. Hexane, chloroform and H2O fractions of GBE exhibit strong inhibition LPS-induced IL-6 pro- duction. Especially, H2O fractions of GBE was the most effective in inhibiting LPD-induced IL-6 production without signifi- cant cytotoxicity in RAW264.7 cells, and reduced the activation of mitogen-activated protein kinases (MAPK) and IkB phosphorylation. These results indicate that H2O fractions of GBE exhibits strong anti-inflammatory effects by inhibition of NF-kB by inhibition of p-38 on MAPK and IkB phosphorylation.

Anti-inflammatory Activity of Solvent Fractions from Ginseng Berry Extract in LPS-Induced RAW264.7 Cells

Disclosed are feed for improving immunity prepared by blending natural substances to strengthen immunity of puppies and sick dogs vulnerable to diseases by the invasion of an external pathogen due to weak immunity; and a method for preparing the same. According to the present invention, the feed for improving an immunity function is prepared by mixing rice flour, powdered skim milk, hydrolysis poultry powder, Echinacea (extract), propolis (liquid), yeast beta gluten (powder), fermented red ginseng (powder), and shiitake mushroom (extract) at a predetermined ratio. A method for preparing feed to improve an immunity function comprises a preparing step, a blending step, an extruding and forming step, a drying step, a crushing and screening step, and a packing step.

Feed for improving immunity and manufacturing method for the feed

Provided are a nanocomposite including a nano-drug delivery system; and a ginseng extract or a ginsenoside isolated therefrom, and a preparation method thereof, in which the nanocomposite may be used for the prevention or treatment of cancer and inflammatory diseases. The metal nanocomposite of the present invention may be prepared in a uniform size without using an additional reducing agent or stabilizing agent in a significantly shortened time, as compared with known metal nanoparticles. Further, since the metal nanocomposite has high solubility in water and high targeting ability for cancer cells, it can be advantageously developed as drugs. Further, the metal nanocomposite exhibits high anti-cancer and anti-inflammatory activities, and thus may be usefully applied to prevention or treatment of cancer and inflammatory diseases. Furthermore, the metal nanocomposite exhibits anti-microbial activity, biofilm-degrading activity, and anti-coagulant activity, and thus may be applied to a variety of industrial fields.

Nano complex comprising a nano drug delivery matrix; and a ginseng extract or a ginsenoside isolated therefrom

The present invention relates to composition for enhancing immunity, comprising ginsenoside F1 as an active ingredient. Specifically, the composition according to the present invention promotes degranulation activity and cell-killing activity of natural killer cells, and increases expressions of cell-killing factors, thereby being effectively used as an immune enhancer.

Composition for enhancing immunity including ginsenoside f1 as an active ingredient

The present invention relates to a composition for preventing or treating allergic skin diseases, containing a fermented extract of ginseng. The fermented extract of ginseng according to the present invention has effects of inhibiting phosphorylation of JNK, a FceRI mediated signaling material, and inhibiting the release of granules (β-hexosaminidase) and cytokines (IL-4), and thus has an excellent therapeutic effect on passive cutaneous anaphylaxis, thereby being able to be usefully used as a pharmaceutical composition for preventing or treating allergic diseases.

Composition for prevention or treatment of allergic skin diseases comprising fermented extract of ginseng

The present invention relates to a method for preparing a fermented ginseng or red ginseng extract enriched with ginsenoide Rd, wherein an extract from the mixture of taproots and rootlets of ginseng or red ginseng is fermented with an enzyme. According to the method for preparing fermented ginseng or red ginseng extract, an enzyme for a food additive is added to shorten a fermentation time, thereby providing economical efficiency, and the extract of the present invention is enriched with ginsenoide Rd without addition of a separate additive for controlling pH or the like.

Preparation for fermented ginseng or red ginseng extract containing increased ginsenoside rd

The present invention relates to a fermented ginseng or red ginseng extract for alleviating atopic dermatitis with enhanced ginsenoside Rd by enzymatically fermenting a mixed extract of primary roots and rootlets of ginseng or primary roots and rootlets of red ginseng. According to the present invention, the ginseng or red ginseng extract for alleviating atopic dermatitis is economical by adding enzyme for a food additive and reducing time of fermentation, and has an advantage of enhancing ginsenoside Rd without the insertion of an extra additive for regulating a pH or the like.

Composition comprising fermented ginseng or red ginseng extract containing increased ginsenoside rd for improving atopic dematitis

The present invention relates to a feed additive composition for pet showing immunity improvement effects and anti-obesity effects by comprising crude saponin of ginseng leaves as an active ingredient The feed additive composition of the present invention is prepared by the steps of: adding 70% ethanol into dried ginseng leaves and extracting the same for 6 to 8 hours at 45 to 90°C; filtering, decompressing, and concentrating the extract and preparing an ethanol extract; adding n-hexane into the ethanol extract, extracting the same, and removing fat-soluble components; adding water and water saturated n-BuOH into the extract in which the fat-soluble components are removed, and dividing the same; and collecting the divided n-BuOH layer, and decompressing and concentrating the same

Feed additives for pet animal containing ginseng leaves

The present invention relates to a production method of a ginseng berry extract which concentrates ginsenoside Re which is a main component of ginseng berries without applying heat to the ginseng berries, and is capable of producing powder from the ginseng berry extract to economically and easily obtain the ginseng berry extract with the reinforced ginsenoside Re from the ginseng berries.

Preparation for the extract of ginseng berry containing increased ginsenoside re

The production method for ginseng berry extract according to the present invention has the advantage not only of allowing non-destructive concentration of ginsenoside Re, which is a main constituent of the ginseng berry, even without the addition of heat but also of making pulverisation possible and producing an extract of intensified ginsenoside Re content from ginseng berries in a straightforward and economic fashion.

Production method for ginseng berry extract with intensified level of ginsenoside re

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