Paolo Pelosi
University of Genoa
1035 Papers
3.7K Citations
Paolo Pelosi is an academic researcher from University of Genoa. The author has contributed to research in topics: Medicine & Mechanical ventilation. The author has an hindex of 93, co-authored 852 publications. Previous affiliations of Paolo Pelosi include University of Insubria & Heidelberg University.
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Papers
Effects of lipopolysaccharide-induced inflammation on initial lung fibrosis during open-lung mechanical ventilation in rats.
Joerg Krebs,Alexander Kolz,Charalambos Tsagogiorgas,Paolo Pelosi,Patricia R. M. Rocco,Thomas Luecke +5 more
TL;DR: In this paper, the impact of pulmonary inflammation on early fibrotic response in rats challenged with increasing doses of lipopolysaccharide (LPS) was assessed and a negative correlation was found between type I and III procollagen-RNA expression and proinflammatory mediators.
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Extracorporeal respiratory support in acute respiratory failure
TL;DR: Mechanical ventilation with high minute ventilation, high levels of peak inspiratory pressures,high levels of positive end-expiratory pressure (PEEP), and high inspiratory fractions of oxygen represents the most common ventilatory management of patients with severe adult respiratory distress syndrome.
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Variability of the Optic Nerve Sheath Diameter on the Basis of Sex and Age in a Cohort of Healthy Volunteers.
Karthikka Chandrapatham,Danilo Cardim,Marek Czosnyka,Alessandro Bertuccio,Anna Di Noto,Francesco Corradi,Joseph Donnelly,Paolo Pelosi,Peter J. Hutchinson,Chiara Robba +9 more
TL;DR: In this article, it was shown that the optic nerve sheath diameter (ONSD) is a good indicator of intracranial pressure (ICP), but there are uncertainties regarding the optimal ONSD threshold, considering age and sex differences in the healthy population.
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Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury
Dietrich Henzler,Alf Schmidt,Zhaolin Xu,N. Ismaiel,Haibo Zhang,Haibo Zhang,Arthur S. Slutsky,Arthur S. Slutsky,Paolo Pelosi +8 more
TL;DR: In experimental ALI in rodents, the respiratory effort was increased by reducing the pressure support during partial ventilatory support and was not associated with worsening ventilator-associated lung injury measured by histologic score and biologic markers.
FG-4497: a new target for acute respiratory distress syndrome?
TL;DR: FG-4497 may be considered a novel pharmacological option targeting endothelial cell repair in lung diseases such as ARDS and further experimental and clinical studies are warranted to better understand the mechanisms of action.
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