Paolo Codega
Memorial Sloan Kettering Cancer Center
12 Papers
27 Citations
Paolo Codega is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Paolo Codega include International School for Advanced Studies & Columbia University.
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Papers
Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche
Paolo Codega,Violeta Silva-Vargas,Alex Paul,Angel R. Maldonado-Soto,Annina M. DeLeo,Erika Pastrana,Fiona Doetsch +6 more
TL;DR: In this paper, GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP (+)CD 133(+)EGFR(+) [aNSC] were isolated from the adult ventricular-subventricular zone.
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Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.
Christian Grommes,Christian Grommes,Alessandro Pastore,Nicolaos Palaskas,Sarah S. Tang,Carl Campos,Derrek Schartz,Paolo Codega,Donna Nichol,Owen Clark,Wan-Ying Hsieh,Daniel Rohle,Marc K. Rosenblum,Agnes Viale,Viviane Tabar,Cameron Brennan,I. T. Gavrilovic,I. T. Gavrilovic,Thomas Kaley,Thomas Kaley,Craig Nolan,Craig Nolan,Antonio M. P. Omuro,Antonio M. P. Omuro,Elena Pentsova,Elena Pentsova,Alissa A. Thomas,Elina Tsyvkin,Elina Tsyvkin,Ariela Noy,Ariela Noy,M. Lia Palomba,M. Lia Palomba,Paul A. Hamlin,Paul A. Hamlin,Craig S. Sauter,Craig S. Sauter,Craig H. Moskowitz,Craig H. Moskowitz,Julia Wolfe,Ahmet Dogan,Minhee Won,Jon Glass,Scott Peak,Enrico C. Lallana,Vaios Hatzoglou,Anne S. Reiner,Philip H. Gutin,Jason T. Huse,Katherine S. Panageas,Thomas G. Graeber,Nikolaus Schultz,Lisa M. DeAngelis,Lisa M. DeAngelis,Ingo K. Mellinghoff,Ingo K. Mellinghoff +55 more
TL;DR: Ibrutinib has substantial activity in patients with relapsed or refractory B-cell lymphoma of the CNS, and combined inhibition of BTK and PI3K/mTOR may augment the ibrut inib response in CD79B-mutant human PCNSLs.
Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells.
Violeta Silva-Vargas,Violeta Silva-Vargas,Angel R. Maldonado-Soto,Dogukan Mizrak,Paolo Codega,Fiona Doetsch,Fiona Doetsch +6 more
TL;DR: The lateral ventricle choroid plexus (LVCP), a primary producer of CSF, is a key niche compartment that translates physiological changes into molecular signals directly affecting neural stem cell behavior.
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Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma.
Christian Grommes,Christian Grommes,Sarah S. Tang,Julia Wolfe,Thomas Kaley,Mariza Daras,Elena Pentsova,Anna F. Piotrowski,Jacqueline B. Stone,Andrew L. Lin,Craig Nolan,Malbora Manne,Paolo Codega,Carl Campos,Agnes Viale,Alissa A. Thomas,Michael F. Berger,Michael F. Berger,Vaios Hatzoglou,Anne S. Reiner,Katherine S. Panageas,Lisa M. DeAngelis,Ingo K. Mellinghoff +22 more
TL;DR: The combination of ibrutinib, HD-MTX, and rituximab was tolerated with an acceptable safety profile and sustained tumor responses were associated with clearance of ctDNA from the CSF.
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A Mosaic World: Puzzles Revealed by Adult Neural Stem Cell Heterogeneity
TL;DR: Key open questions remain about stem cell dynamics in vivo and the lineage relationship between qN SCs and aNSCs under homeostasis and regeneration, as well as context‐dependent plasticity of regionally distinct adult N SCs under different external stimuli.
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